Montagnana Martina, Lippi Giuseppe, Franchini Massimo, Targher Giovanni, Cesare Guidi Gian
Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, Universita degli Studi di Verona, Italy.
Ann Med. 2008;40(5):360-75. doi: 10.1080/07853890801964930.
Sudden cardiac death (SCD), also known as sudden arrest, is a major health problem worldwide. It is usually defined as an unexpected death from a cardiac cause occurring within a short time in a person with or without preexisting heart disease. The pathogenesis of SCD is complex and multifaceted. A dynamic triggering factor usually interacts with an underlying heart disease, either genetically determined or acquired, and the final outcome is the development of lethal tachyarrhythmias or, less frequently, bradycardia. It has increasingly been highlighted that a reliable clinical and diagnostic approach might be effective to unmask the most important genetic and environmental factors, allowing the construction of a rational personalized medicine framework that can be applied in both the preclinical and clinical settings of SCD. The aim of the present article is to provide a concise overview of prevalence, pathogenesis, clinical presentation, and diagnostic approach to this challenging disorder.
心脏性猝死（SCD），也称为心脏骤停，是全球范围内的一个主要健康问题。它通常被定义为在患有或不患有既往心脏病的个体中，在短时间内由心脏原因导致的意外死亡。SCD的发病机制复杂且多方面。一个动态触发因素通常与潜在的心脏病相互作用，这种心脏病可以是遗传决定的或后天获得的，最终结果是发生致命性快速心律失常，或较少见的心动过缓。越来越多的研究强调，一种可靠的临床和诊断方法可能有效地揭示最重要的遗传和环境因素，从而构建一个合理的个性化医疗框架，该框架可应用于SCD的临床前和临床环境。本文的目的是对这种具有挑战性的疾病的患病率、发病机制、临床表现和诊断方法进行简要概述。
