Hrachovy R A, Glaze D G, Frost J D
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
Epilepsia. 1991 Mar-Apr;32(2):212-4. doi: 10.1111/j.1528-1157.1991.tb05246.x.
The spontaneous remission rate and long-term outcome in 44 patients with infantile spasms not treated with hormonal drugs were studied. The cumulative spontaneous remission rate during the first 12 months after onset of infantile spasms, as determined by retrospective analysis, was as follows: 1 month, 2%; 2 months, 2%; 3 months, 5%; 4 months, 7%; 5 months, 9%; 6 months, 11%; 7 months, 11%; 8 months, 14%; 9 months, 16%; 10 months, 18%; 11 months, 25%; 12 months, 25%. The average age at follow-up was 80 months. Nine percent of patients had normal development or only mild impairment. The remainder showed various degrees of retardation. These data should be useful in the design and interpretation of therapeutic drug trials in patients with infantile spasms.
对44例未接受激素药物治疗的婴儿痉挛症患者的自然缓解率和长期预后进行了研究。通过回顾性分析确定，婴儿痉挛症发作后头12个月的累积自然缓解率如下：1个月，2%；2个月，2%；3个月，5%；4个月，7%；5个月，9%；6个月，11%；7个月，11%；8个月，14%；9个月，16%；10个月，18%；11个月，25%；12个月，25%。随访时的平均年龄为80个月。9%的患者发育正常或仅有轻度损害。其余患者表现出不同程度的发育迟缓。这些数据应有助于婴儿痉挛症患者治疗性药物试验的设计和解释。
