Clamp P J
Department of ENT, Royal United Hospital Bath NHS Trust, Bath, UK.
J Laryngol Otol. 2008 Jul;122(7):687-90. doi: 10.1017/S0022215108002661. Epub 2008 May 19.
To determine the expansile and absorptive properties of the expandable ear wick when tested with commonly prescribed ear drop preparations.
This in vitro study assessed wick expansion and absorption of drops when different ear drop preparations were applied. Nine commonly used ear drop preparations were tested (Gentisone HC, Sofradex, Otomize, Betnesol, Exocin, Canesten, Locorten-Vioform, EarCalm and ichthammol glycerin) with a standard expandable ear wick.
Weight, length and width of otowick following exposure to ear drops.
There was a marked difference in the absorption and expansion of the otowick when different drops were used. This corresponded to the aqueous or oil base of each preparation. All aqueous ear drop preparations (i.e. Gentisone HC, Sofradex, Otomize, Betnesol, Exocin and EarCalm) produced similar rates of absorption into, and expansion of, the otowick. The oil-based ear drop preparations (i.e. Canesten, Locorten-Vioform and ichthammol glycerin) failed to expand the wick and showed poor rates of absorption into the wick.
Expandable ear wicks should only be used in conjunction with aqueous ear drops. When using expandable otowicks as an adjunct to treating fungal otitis externa, acetic acid ear drops should be prescribed, as all other anti-fungal drops are oil-based.
在用常用的滴耳剂制剂进行测试时,确定可膨胀耳烛芯的膨胀和吸收特性。
这项体外研究评估了应用不同滴耳剂制剂时烛芯的膨胀和滴耳剂的吸收情况。使用标准的可膨胀耳烛芯对九种常用的滴耳剂制剂(氢化可的松泼尼松、索夫拉得克斯、奥拓米兹、倍他米松、依诺沙星、凯妮汀、氯碘羟喹、耳静和鱼石脂甘油)进行了测试。
接触滴耳剂后耳烛芯的重量、长度和宽度。
使用不同的滴耳剂时,耳烛芯的吸收和膨胀存在显著差异。这与每种制剂的水性或油性基质相对应。所有水性滴耳剂制剂(即氢化可的松泼尼松、索夫拉得克斯、奥拓米兹、倍他米松、依诺沙星和耳静)对耳烛芯的吸收和膨胀速率相似。油性滴耳剂制剂(即凯妮汀、氯碘羟喹和鱼石脂甘油)未能使烛芯膨胀,且对烛芯的吸收率较低。
可膨胀耳烛芯应仅与水性滴耳剂联合使用。当使用可膨胀耳烛芯辅助治疗外耳道真菌性炎症时,应开具醋酸滴耳剂,因为所有其他抗真菌滴耳剂都是油性的。