van Deventer M Oskar
Hannie Schaftstraat 62, DL Leidschendam, Netherlands.
Med Hypotheses. 2008 Sep;71(3):335-9. doi: 10.1016/j.mehy.2008.03.040. Epub 2008 May 15.
Fake treatments work. That is a well established medical fact. This is why the golden standard of evidence-based medicine requires double-blind testing. Both real and fake (also known as placebo) treatments are administered in order to be able to distinguish the effects of the treatment-under-test from the placebo effect. Given the medically proven fact that fake treatments work, doctors could include fake treatments in their medical repertoire. However, this poses an ethical dilemma. On the one hand the doctor does not want to lie to his patient. On the other hand, the effect of the fake treatment would diminish if the patient knows it is fake. For this reason, fake treatments are typically left to practitioners of so-called alternative medicine who are often not even aware of the ethical dilemma. The central hypothesis of this article is that the doctor does not have to lie, and that truthfully administering fake treatments would not render these ineffective. A proper term for this type of treatment "meta-placebo". The placebo effect is based on the healing belief of getting administered a real treatment. The meta-placebo effect is based on the healing belief that even fake/placebo treatments have positive effects. That is, if both the doctor and the patient believe in the healing powers of the fake treatment, it does not matter that both know the treatment is fake. If the meta-placebo effect exists, it would solve several of the doctor's dilemma's. First of all, he would not have to lie to the patient when applying a fake treatment. Secondly, by having fake treatments in his medical repertoire, the doctor could keep patients in the regular medical circuit and keep monitoring the patient's syndrome. Thirdly, the doctor could keep the patient away from the medical and financial risks associated with alternative medicine. Unlike the well-established placebo effect, the meta-placebo effect is still a medical hypothesis. The hypothesis shall have to be tested experimentally, before "meta-placebo" treatments can become evidence-based medicine. Such validation involves several medical philosophical complications. How can the hypothesis be tested following the golden double-blind standard? What syndrome would be suited for a meta-placebo-experiment? What would a treatment in a meta-placebo experiment look like? How can meta-placebo be distinguish from placebo? What ethical aspects do meta-placebo's have? This article discusses these questions in detail.
假治疗是有效的。这是一个已被充分证实的医学事实。这就是为什么循证医学的黄金标准要求进行双盲测试。给予真实治疗和假治疗(也称为安慰剂),以便能够将受试治疗的效果与安慰剂效应区分开来。鉴于医学上已证实假治疗是有效的这一事实,医生可以将假治疗纳入其医疗方法中。然而,这带来了一个伦理困境。一方面,医生不想对他的病人说谎。另一方面,如果病人知道治疗是假的,假治疗的效果就会减弱。因此,假治疗通常留给所谓替代医学的从业者,而他们往往甚至没有意识到这种伦理困境。本文的核心假设是,医生不必说谎,如实给予假治疗不会使其无效。这种治疗类型的一个恰当术语是“元安慰剂”。安慰剂效应基于接受真实治疗的治愈信念。元安慰剂效应基于这样一种治愈信念,即即使是假的/安慰剂治疗也有积极效果。也就是说,如果医生和病人都相信假治疗的治愈能力,那么两人都知道治疗是假的也没关系。如果元安慰剂效应存在,它将解决医生的几个困境。首先,在应用假治疗时他不必对病人说谎。其次,通过在其医疗方法中采用假治疗,医生可以让病人留在常规医疗体系中并持续监测病人的症状。第三,医生可以使病人远离与替代医学相关的医疗和经济风险。与已被充分证实的安慰剂效应不同,元安慰剂效应仍然是一个医学假设。在“元安慰剂”治疗成为循证医学之前,这个假设必须通过实验进行检验。这种验证涉及几个医学哲学上的复杂问题。如何按照黄金双盲标准对这个假设进行检验?哪种症状适合进行元安慰剂实验?元安慰剂实验中的治疗会是什么样的?如何将元安慰剂与安慰剂区分开来?元安慰剂有哪些伦理方面的问题?本文将详细讨论这些问题。