石松寄生新生物碱石松素A - C对乙酰胆碱酯酶具有抑制作用。
Lycoparins A-C, new alkaloids from Lycopodium casuarinoides inhibiting acetylcholinesterase.
作者信息
Hirasawa Yusuke, Kato Eri, Kobayashi Jun'ichi, Kawahara Nobuo, Goda Yukihiro, Shiro Motoo, Morita Hiroshi
机构信息
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
出版信息
Bioorg Med Chem. 2008 Jun 1;16(11):6167-71. doi: 10.1016/j.bmc.2008.04.044. Epub 2008 Apr 25.
Three new Lycopodium alkaloids, lycoparins A-C (1-3), have been isolated from the club moss Lycopodium casuarinoides. Structures and stereochemistry of 1-3 were elucidated on the basis of 2D NMR correlations. Lycoparins C (3) exhibited an inhibitory activity against acetylcholinesterase, while lycoparins A (1) and B (2) did not show activity.
从石松科植物南洋石松（Lycopodium casuarinoides）中分离出了三种新的石松生物碱，即石松素A-C（1-3）。基于二维核磁共振相关技术阐明了1-3的结构和立体化学。石松素C（3）对乙酰胆碱酯酶具有抑制活性，而石松素A（1）和B（2）则无此活性。
Zotero 插件