锯齿石松碱D和E，从锯齿石松变种锯齿石松中分离得到的新石松生物碱。
Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum.
作者信息
Kubota Takaaki, Yahata Hiroko, Yamamoto Sunao, Hayashi Shigeki, Shibata Toshiro, Kobayashi Jun'ichi
机构信息
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
出版信息
Bioorg Med Chem Lett. 2009 Jul 1;19(13):3577-80. doi: 10.1016/j.bmcl.2009.04.146. Epub 2009 May 5.
Two new Lycopodium alkaloids, serratezomines D (1) and E (2), were isolated from the club moss Lycopodium serratum var. serratum. Serratezomine D (1) is a new lucidine-type alkaloid, while serratezomine E (2) is a new phlegmarane-type alkaloid. The structures and relative stereochemistry of 1 and 2 were elucidated on the basis of spectroscopic data. Serratezomine D (1) exhibited an inhibitory activity against acetylcholinesterase.
从石松科植物石松的锯齿变种中分离出两种新的石松生物碱，锯齿石松碱D（1）和E（2）。锯齿石松碱D（1）是一种新的亮氨酸型生物碱，而锯齿石松碱E（2）是一种新的蔓生烷型生物碱。根据光谱数据阐明了1和2的结构及相对立体化学。锯齿石松碱D（1）对乙酰胆碱酯酶具有抑制活性。
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