Cytomegalovirus colitis and wasting.

Disseminated cytomegalovirus (CMV) infection is associated with significant and progressive depletion of body cell mass and body fat in patients with the acquired immune deficiency syndrome (AIDS). In a study examining the effect of ganciclovir on wasting in AIDS patients with disseminated CMV infection, it was found that patients receiving ganciclovir had significant improvement in such variables as body cell mass, body fat, body weight, and total body energy content when compared with those not receiving ganciclovir. The repletion of body cell mass observed in AIDS patients with disseminated CMV infection who are successfully treated with ganciclovir appears to be associated with improved quality of life and prolongation of survival.