Akkol Esra Küpeli, Yalçin Funda Nuray, Kaya Duygu, Caliş Ihsan, Yesilada Erdem, Ersöz Tayfun
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, Ankara, Turkey.
J Ethnopharmacol. 2008 Jun 19;118(1):166-72. doi: 10.1016/j.jep.2008.04.001. Epub 2008 Apr 11.
Several Lamium species have been used to relieve pain in arthritic ailments in Turkish folk medicine.
To evaluate the anti-inflammatory and antinociceptive activities of different extracts prepared with methanol, dichloromethane, n-butanol and water from the aerial parts of some Lamium species of Turkish origin.
Lamium eriocephalum subsp. eriocephalum, Lamium garganicum subsp. laevigatum, Lamium garganicum subsp. pulchrum and Lamium purpureum var. purpureum (Lamiaceae); for the anti-inflammatory activity, carrageenan-induced hind paw edema model, PGE(2)-induced hind paw edema model, and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema model and for the antinociceptive activity p-benzoquinone (PBQ)-induced writhing test in mice were employed.
The n-butanol extracts of Lamium garganicum subsp. laevigatum (LGL-BuOH), Lamium garganicum subsp. pulchrum (LGP-BuOH), and Lamium purpureum var. purpureum (LPP-BuOH) exhibited notable inhibition (16.5-28.9, 14.5-26.9, 12.3-21.5%, resp.) in carrageenan-induced hind paw edema model at doses of 200mg/kg without inducing any gastric damage. The LGL-BuOH (7.1-30.4%) and LGP-BuOH (5.9-24.1%) extracts also displayed potent anti-inflammatory activity against PGE(2)-induced hind paw edema model. LGL-BuOH and LGP-BuOH were also found to exhibit remarkable antinociceptive activity in p-benzoquinone-induced abdominal constriction test at a dose of 200 mg/kg (25.0 and 24.3%, respectively).
The experimental data demonstrated that Lamium garganicum subsp. laevigatum and Lamium garganicum subsp. pulchrum displayed remarkable anti-inflammatory and antinociceptive activities.
在土耳其民间医学中，多种野芝麻属植物被用于缓解关节炎疾病的疼痛。
评估用甲醇、二氯甲烷、正丁醇和水从一些土耳其原产野芝麻属植物地上部分制备的不同提取物的抗炎和镇痛活性。
绵毛野芝麻亚种绵毛野芝麻、加加尼野芝麻亚种光滑加加尼野芝麻、加加尼野芝麻亚种美丽加加尼野芝麻和紫花野芝麻变种紫花野芝麻（唇形科）；对于抗炎活性，采用角叉菜胶诱导的后爪水肿模型、前列腺素E2（PGE₂）诱导的后爪水肿模型和12-O-十四烷酰佛波醇-13-乙酸酯（TPA）诱导的小鼠耳水肿模型，对于镇痛活性，采用对苯醌（PBQ）诱导的小鼠扭体试验。
加加尼野芝麻亚种光滑加加尼野芝麻（LGL-BuOH）、加加尼野芝麻亚种美丽加加尼野芝麻（LGP-BuOH）和紫花野芝麻变种紫花野芝麻（LPP-BuOH）的正丁醇提取物在200mg/kg剂量下对角叉菜胶诱导的后爪水肿模型表现出显著抑制作用（分别为16.5 - 28.9%、14.5 - 26.9%、12.3 - 21.5%），且未引起任何胃损伤。LGL-BuOH（7.1 - 30.4%）和LGP-BuOH（5.9 - 24.1%）提取物对PGE₂诱导的后爪水肿模型也显示出强效抗炎活性。在200mg/kg剂量的对苯醌诱导的腹部收缩试验中，LGL-BuOH和LGP-BuOH也表现出显著的镇痛活性（分别为25.0%和24.3%）。
实验数据表明，加加尼野芝麻亚种光滑加加尼野芝麻和加加尼野芝麻亚种美丽加加尼野芝麻具有显著的抗炎和镇痛活性。
