Finnie J W, Manavis J, Blumbergs P C
Hanson Institute Centre for Neurological Diseases, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia.
Vet Pathol. 2008 May;45(3):307-9. doi: 10.1354/vp.45-3-307.
Sheep, particularly lambs, with high circulating levels of Clostridium perfringens type D epsilon toxin develop severe neurologic signs and often die suddenly. On microscopic examination, in the brain, there is microvascular endothelial injury and diffuse vasogenic edema. The aquaporin (AQP) family of membrane water-channel proteins, especially AQP-4, is important in the regulation of water balance in the brain and facilitates reabsorption of excess fluid. In rats given epsilon toxin, generalized cerebral edema was demonstrated by marked albumin extravasation and was correlated with widespread upregulation of AQP-4 in astrocytes. These results suggest that AQP-4 has a role in the clearance of edema fluid from brains damaged by this clostridial toxin.
体内产气荚膜梭菌D型ε毒素循环水平高的绵羊，尤其是羔羊，会出现严重的神经症状，且常常突然死亡。在显微镜检查下，大脑中存在微血管内皮损伤和弥漫性血管源性水肿。膜水通道蛋白的水通道蛋白（AQP）家族，尤其是AQP - 4，在调节大脑水平衡以及促进多余液体的重吸收方面起着重要作用。在给予ε毒素的大鼠中，明显的白蛋白外渗表明出现了全身性脑水肿，并且这与星形胶质细胞中AQP - 4的广泛上调相关。这些结果表明，AQP - 4在清除受这种梭菌毒素损伤的大脑中的水肿液方面发挥作用。
