Gabis Lidia, Azizian Allen, DeVincent Carla, Tudorica Alina, Kesner-Baruch Yael, Roche Patricia, Pomeroy John
Weinberg Child Development Center, Safra Children's Hospital, Tel Hashomer, Israel.
J Child Neurol. 2008 Jul;23(7):766-74. doi: 10.1177/0883073808315423. Epub 2008 May 16.
This study assessed metabolic functioning of regional brain areas to address whether there is a neurometabolic profile reflecting the underlying neuropathology in individuals with autism spectrum disorders, and if varied profiles correlate with the clinical subtypes. Thirteen children (7-16 years) with autism spectrum disorders and 8 typically developing children were compared on (1)H-magnetic resonance spectroscopy data collected from hippocampus-amygdala and cerebellar regions. The autism spectrum disorder group had significantly lower N-acetyl-aspartate/creatine ratios bilaterally in the hippocampus-amygdala but not cerebellum, whereas myo-inositol/creatine was significantly increased in all measured regions. Choline/creatine was also significantly elevated in the left hippocampus-amygdala and cerebellar regions of children with autism spectrum disorder. Comparisons within the autism spectrum disorder group when clinically subdivided by history of speech delay revealed significant metabolic ratio differences. Magnetic resonance spectroscopy can provide important information regarding abnormal brain metabolism and clinical classification in autism spectrum disorders.
本研究评估了局部脑区的代谢功能，以探讨是否存在一种神经代谢特征反映自闭症谱系障碍个体潜在的神经病理学特征，以及不同的特征是否与临床亚型相关。对13名患有自闭症谱系障碍的儿童（7 - 16岁）和8名发育正常的儿童进行了比较，比较的依据是从海马体 - 杏仁核和小脑区域收集的氢磁共振波谱数据。自闭症谱系障碍组双侧海马体 - 杏仁核中的N - 乙酰天门冬氨酸/肌酸比值显著低于发育正常组，但小脑区域无此差异，而在所有测量区域中，肌醇/肌酸显著升高。自闭症谱系障碍儿童的左侧海马体 - 杏仁核和小脑区域的胆碱/肌酸也显著升高。当根据语言发育迟缓病史对自闭症谱系障碍组进行临床细分时，组内比较显示代谢比值存在显著差异。磁共振波谱可以提供有关自闭症谱系障碍中脑代谢异常和临床分类的重要信息。
