Bilate Angelina M B, Cunha-Neto Edecio
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Rev Inst Med Trop Sao Paulo. 2008 Mar-Apr;50(2):67-74. doi: 10.1590/s0036-46652008000200001.
Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy known as Chagas disease cardiomyopathy (CCC). Data from both murine models and human studies support the view that an autoimmune response as well as a parasite-driven immune response involving inflammatory cytokines and chemokines may both play a role in generating the heart lesions leading to CCC. This review aims to summarize recent advances in the understanding of the immunopathogenesis of Chagas disease cardiomyopathy.
恰加斯病仍然是一个重大的公共卫生问题，因为在拉丁美洲约有1000万人仍感染克氏锥虫。初次感染数十年后，30%的个体可能会发展出一种慢性炎症性心肌病，称为恰加斯病心肌病（CCC）。来自小鼠模型和人体研究的数据均支持这样的观点，即自身免疫反应以及涉及炎性细胞因子和趋化因子的寄生虫驱动的免疫反应，可能在导致CCC的心脏病变形成中均发挥作用。本综述旨在总结恰加斯病心肌病免疫发病机制理解方面的最新进展。
