Avetisov S E, Polunin G S, Sheremet N L, Muranov K O, Makarov I A, Fedorov A A, Karpova O E, Ostrovskiĭ M A
Vestn Oftalmol. 2008 Mar-Apr;124(2):8-12.
To study the mechanisms of action of new-generation anticataract drugs, it is necessary to have an accessible and adequate model of age-related cataract. A model of UV-induced cataract is pathogenetically closest to that of age-related cataract. A prolonged rat model of UV-induced cataract developing within 10 months is proposed; the clinical features of UV-induced cataract have been established at different stages of its development. A moderate homogeneous cloud-like lenticular opacity was observed at the end of the experiment; a less pronounced homogeneous opacity was seen in the anterior and posterior cortical layers. Cataract development was assessed by the appraisal method using the developed rat lenticular transparency scale, as well as by microdensitometry of biomicroscopic lenticular optical sections. Within the proposed model, the pathomorphological lenticular changes are largely similar to the histological pattern of age-related cataract.
为研究新一代抗白内障药物的作用机制，有必要建立一个易于获取且合适的年龄相关性白内障模型。紫外线诱导性白内障模型在发病机制上与年龄相关性白内障最为接近。本文提出了一种在10个月内形成的紫外线诱导性白内障的长期大鼠模型；已确定了紫外线诱导性白内障在其发展不同阶段的临床特征。实验结束时观察到晶状体呈中度均匀的云雾状混浊；在前、后皮质层可见不太明显的均匀混浊。采用所建立的大鼠晶状体透明度量表评估法以及对生物显微镜下晶状体光学切片进行显微密度测定来评估白内障的发展情况。在所提出的模型中，晶状体的病理形态学变化在很大程度上与年龄相关性白内障的组织学模式相似。
