[伴侣样抗白内障药物，晶状体蛋白抗聚集剂。通讯4. 二肽和四肽混合物对紫外线诱导的大鼠长期白内障模型影响的研究]
[Chaperon-like anticataract agents, the antiaggregants of lens crystallin. Communication 4. Study of the effect of a mixture of di- and tetrapeptides on a prolonged rat model of UV-induced cataract].
作者信息
Avetisov S E, Polunin G S, Sheremet N L, Makarov I A, Fedorov A A, Karpova O E, Muranov K O, Dizhevskaia A K, Soustov L V, Chelnokov E V, Bitiurin N M, Sapogova N V, Nemov V V, Bodyrev A A, Ostrovskiĭ M A
出版信息
Vestn Oftalmol. 2008 Mar-Apr;124(2):12-6.
There is a potential of therapeutic action on certain stages of caractogenesis, in particular on the aggregation of water-soluble proteins of cytoplasmic lens fiber cells, giving rise to insoluble protein complexes. The effect of a combined preparation (N-acetyl carnosine and D-patethine), acting by the chaperon-like mechanism, was studied in vivo on a prolonged rat model of UV-induced cataract. The use of the combined preparation consisting of a mixture of peptides of N-acetyl carnosine and D-patethine in a ratio of 1:1 as ocular instillations and intraperitoneal injections could slow down the development of UV-induced cataract in vivo. Pathomorphological studies suggest that the combined preparation has a protective effect on lens tissue when the rat model of UV-induced cataract is employed.
在白内障发生的某些阶段存在治疗作用的潜力，特别是对细胞质晶状体纤维细胞中水溶性蛋白质的聚集，这些蛋白质会形成不溶性蛋白质复合物。通过类伴侣机制起作用的联合制剂（N-乙酰肌肽和D-泛硫乙胺）在紫外线诱导的白内障大鼠长期模型上进行了体内研究。以1:1比例混合的N-乙酰肌肽和D-泛硫乙胺肽组成的联合制剂作为眼内滴注和腹腔注射使用，可以减缓紫外线诱导的白内障在体内的发展。病理形态学研究表明，当采用紫外线诱导的白内障大鼠模型时，联合制剂对晶状体组织具有保护作用。
Zotero 插件