DuBeshter B
Department of Obstetrics and Gynecology, University of Rochester School of Medicine, Strong Memorial Hospital, New York.
J Reprod Med. 1991 Jan;36(1):9-13.
The patient with gestational trophoblastic neoplasia faces a number of risks; the greatest is the failure of current treatment to bring about remission. Based on a review of past experience, a number of risk factors associated with failure of single-agent chemotherapy were identified, and the subsequent utilization of combination chemotherapy led to an improved outcome. An analysis of more recent experience has identified factors associated with the failure of standard combination chemotherapy, and it is hoped that the development of new treatments will again improve the outcome. This review provides a perspective on known high-risk factors in light of contemporary treatment.
妊娠滋养细胞肿瘤患者面临诸多风险；其中最大的风险是当前治疗未能实现缓解。基于对既往经验的回顾，确定了一些与单药化疗失败相关的风险因素，随后联合化疗的应用使治疗效果得到改善。对近期经验的分析确定了与标准联合化疗失败相关的因素，希望新治疗方法的开发能再次改善治疗效果。本综述根据当代治疗方法对已知的高风险因素进行了阐述。
