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Pyrophosphate formation as the most efficient condensation reaction of activated nucleotides.

作者信息

Rodriguez L, Orgel L E

机构信息

Salk Institute for Biological Studies, San Diego, CA 92122.

出版信息

J Mol Evol. 1991 Feb;32(2):101-4. doi: 10.1007/BF02515382.

DOI:10.1007/BF02515382
PMID:1848905
Abstract

When an oligonucleotide primer pG10 is incubated with the nucleotide analogue 9-[3-hydroxy-2-(hydroxymethyl)prop-1-yl] guanine diphosphate (pGp, I) in the presence of poly(C), addition of the monomer occurs almost exclusively at the 5'-terminal phosphate rather than the 3'-terminal cis-glycol. The implications of this finding in the context of prebiotic condensation reactions are discussed.

摘要

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本文引用的文献

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Some acyclic analogues of nucleotides and their template-directed reactions.一些核苷酸的无环类似物及其模板导向反应。
J Mol Evol. 1989;28:367-73. doi: 10.1007/BF02603071.
2
Template-directed synthesis of novel, nucleic acid-like structures.新型核酸样结构的模板导向合成。
Science. 1985 May 3;228:585-7. doi: 10.1126/science.228.4699.585.
3
Oligomerization of (guanosine 5'-phosphor)-2-methylimidazolide on poly(C). An RNA polymerase model.（鸟苷 5'-磷酸）-2-甲基咪唑酯在聚（C）上的寡聚化。一种RNA聚合酶模型。
作为亲核试剂的核苷酸：核苷酸与磷酸咪唑酯活化鸟苷的反应
Orig Life Evol Biosph. 1991;21(4):199-217. doi: 10.1007/BF01809856.
4
Selective cleavage of pyrophosphate linkages.焦磷酸键的选择性裂解
Nucleic Acids Res. 1992 Nov 11;20(21):5749-52. doi: 10.1093/nar/20.21.5749.
J Mol Biol. 1982 Nov 25;162(1):201-17. doi: 10.1016/0022-2836(82)90169-3.
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Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates.RNA随机共聚物上的非酶模板导向合成。聚（C，U）模板。
J Mol Biol. 1984 Jun 25;176(2):279-306. doi: 10.1016/0022-2836(84)90425-x.
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Evolution of the genetic apparatus.遗传机制的进化。
J Mol Biol. 1968 Dec;38(3):381-93. doi: 10.1016/0022-2836(68)90393-8.
6
Nonenzymatic synthesis of oligoadenylates on a polyuridylic acid template.在聚尿苷酸模板上进行寡聚腺苷酸的非酶促合成。
Proc Natl Acad Sci U S A. 1968 Mar;59(3):726-33. doi: 10.1073/pnas.59.3.726.
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Nucleic acid-like structures. II. Polynucleotide analogues as possible primitive precursors of nucleic acids.
Orig Life Evol Biosph. 1987;17(3-4):351-7. doi: 10.1007/BF02386473.
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Template-directed synthesis of acyclic oligonucleotide analogues.
J Mol Evol. 1988;28(1-2):3-6. doi: 10.1007/BF02143492.
9
Cyclization of nucleotide analogues as an obstacle to polymerization.
J Mol Evol. 1988;28(1-2):170-1. doi: 10.1007/BF02143509.
10
Nonenzymatic template-directed synthesis of informational macromolecules.信息大分子的非酶模板导向合成。
Cold Spring Harb Symp Quant Biol. 1987;52:41-51. doi: 10.1101/sqb.1987.052.01.008.