• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Cyclization of nucleotide analogues as an obstacle to polymerization.

作者信息

Hill A R, Nord L D, Orgel L E, Robins R K

机构信息

Salk Institute for Biological Studies, San Diego, California 92138.

出版信息

J Mol Evol. 1988;28(1-2):170-1. doi: 10.1007/BF02143509.

DOI:10.1007/BF02143509
PMID:3148737
Abstract

Cyclization of activated nucleotide analogues by intramolecular phosphodiester-bond formation is likely to compete very effectively with template-directed condensation except in the cases of ribo- and arabinonucleotides. This could have excluded derivatives of most sugars from growing polyribonucleotide chains and thus reduced chain-termination in prebiotic polynucleotide synthesis.

摘要

相似文献

1
Cyclization of nucleotide analogues as an obstacle to polymerization.
J Mol Evol. 1988;28(1-2):170-1. doi: 10.1007/BF02143509.
2
Template-directed oligomerization of 5'-deoxy-5'-nucleosideacetic acid derivatives.5'-脱氧-5'-核苷乙酸衍生物的模板导向寡聚化
Orig Life Evol Biosph. 1990;20:151-60. doi: 10.1007/BF01808276.
3
Self-condensation of activated dinucleotides on polynucleotide templates with alternating sequences.活化二核苷酸在具有交替序列的多核苷酸模板上的自身缩合。
J Mol Evol. 1979 Dec;14(4):243-50. doi: 10.1007/BF01732491.
4
The cyclization of arabinosyladenine-5'-phosphorimidazolide.阿拉伯糖基腺嘌呤-5'-磷酰咪唑的环化作用。
J Mol Evol. 1991;32:358-9. doi: 10.1007/BF02101274.
5
Template-directed synthesis using the heterogeneous templates produced by montmorillonite catalysis. A possible bridge between the prebiotic and RNA worlds.利用蒙脱石催化产生的非均相模板进行模板导向合成。益生元世界与RNA世界之间可能的桥梁。
J Am Chem Soc. 1997 Aug 6;119(31):7197-201. doi: 10.1021/ja970422h.
6
Some acyclic analogues of nucleotides and their template-directed reactions.一些核苷酸的无环类似物及其模板导向反应。
J Mol Evol. 1989;28:367-73. doi: 10.1007/BF02603071.
7
The biogeochemical cycle of the adsorbed template. I: Formation of the template.
Orig Life Evol Biosph. 1987;17(2):135-48. doi: 10.1007/BF01808241.
8
Studies on precellular evolution: the encapsulation of polyribonucleotides by liposomes.
Adv Space Res. 1986;6(11):39-43. doi: 10.1016/0273-1177(86)90273-5.
9
Oligomerization of 3'-amino-3'deoxyguanosine-5'phosphorimidazolidate on a d(CpCpCpCpC) template.3'-氨基-3'-脱氧鸟苷-5'-磷酰咪唑啉酸酯在d(CpCpCpCpC)模板上的寡聚化。
J Mol Evol. 1987;25:97-9. doi: 10.1007/BF02101750.
10
Synthesis of 5'-deoxy-5'-nucleosideacetic acid derivatives.5'-脱氧-5'-核苷乙酸衍生物的合成
Nucleosides Nucleotides. 1990;9(6):771-85. doi: 10.1080/15257779008043143.

引用本文的文献

1
On the aqueous origins of the condensation polymers of life.生命缩聚物的水溶液起源。
Nat Rev Chem. 2024 Nov;8(11):817-832. doi: 10.1038/s41570-024-00648-5. Epub 2024 Sep 27.
2
Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension.非酶模板指导引物延伸合成 N3'-P5'-连接的膦酸酯 DNA。
J Am Chem Soc. 2013 Jan 16;135(2):924-32. doi: 10.1021/ja311164j. Epub 2013 Jan 7.
3
The origins of cellular life.细胞生命的起源。

本文引用的文献

1
Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates.RNA随机共聚物上的非酶模板导向合成。聚（C，U）模板。
J Mol Biol. 1984 Jun 25;176(2):279-306. doi: 10.1016/0022-2836(84)90425-x.
2
Nucleic acid-like structures. II. Polynucleotide analogues as possible primitive precursors of nucleic acids.
Orig Life Evol Biosph. 1987;17(3-4):351-7. doi: 10.1007/BF02386473.
3
Synthesis, structure, and biological activity of certain 2-deoxy-beta-D-ribo-hexopyranosyl nucleosides and nucleotides.某些2-脱氧-β-D-核糖己吡喃糖基核苷和核苷酸的合成、结构及生物活性
Cold Spring Harb Perspect Biol. 2010 Sep;2(9):a002212. doi: 10.1101/cshperspect.a002212. Epub 2010 May 19.
4
Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers.使用2'-氨基-2',3'-二脱氧核糖核苷-5'-磷酰咪唑单体进行高效快速的模板导向核酸复制。
J Am Chem Soc. 2009 Oct 14;131(40):14560-70. doi: 10.1021/ja906557v.
5
Selectivity of montmorillonite catalyzed prebiotic reactions of D, L-nucleotides.蒙脱石催化D，L-核苷酸益生元反应的选择性。
Orig Life Evol Biosph. 2007 Feb;37(1):3-26. doi: 10.1007/s11084-006-9013-x. Epub 2006 Dec 8.
6
Polymerization of the cyclic pyrophosphates of nucleosides and their analogues.核苷及其类似物的环状焦磷酸盐的聚合作用。
J Mol Evol. 1990;30:97-103. doi: 10.1007/BF02099935.
7
Oligomerization reactions of deoxyribonucleotides on montmorillonite clay: the effect of mononucleotide structure on phosphodiester bond formation.脱氧核糖核苷酸在蒙脱石黏土上的寡聚反应：单核苷酸结构对磷酸二酯键形成的影响。
Orig Life Evol Biosph. 1989;19:609-19. doi: 10.1007/BF01808121.
8
The cyclization of arabinosyladenine-5'-phosphorimidazolide.阿拉伯糖基腺嘌呤-5'-磷酰咪唑的环化作用。
J Mol Evol. 1991;32:358-9. doi: 10.1007/BF02101274.
9
Attempted nonenzymatic template-directed oligomerizations on a polyadenylic acid template: implications for the nature of the first genetic material.在聚腺苷酸模板上进行的非酶促模板导向寡聚化反应：对首个遗传物质本质的启示
J Mol Evol. 1991;32:282-8. doi: 10.1007/BF02102185.
10
Disulfide-linked oligonucleotide phosphorothioates: novel analogues of nucleic acids.二硫键连接的寡核苷酸硫代磷酸酯：新型核酸类似物
J Mol Evol. 1991;32:274-7. doi: 10.1007/BF02102183.
J Med Chem. 1987 Jun;30(6):1044-54. doi: 10.1021/jm00389a015.
4
Evolution of the genetic apparatus: a review.遗传机制的演变：综述
Cold Spring Harb Symp Quant Biol. 1987;52:9-16. doi: 10.1101/sqb.1987.052.01.004.
5
The case for an ancestral genetic system involving simple analogues of the nucleotides.关于一个涉及核苷酸简单类似物的祖传遗传系统的情况。
Proc Natl Acad Sci U S A. 1987 Jul;84(13):4398-402. doi: 10.1073/pnas.84.13.4398.
6
Studies of oligoadenylate formation on a poly (U) template.在聚（U）模板上形成寡腺苷酸的研究。
J Mol Evol. 1979 Mar 15;12(3):237-57. doi: 10.1007/BF01732341.