Lu Liang, Zhang Wei, Carter Rich G
Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, Oregon 97331, USA.
J Am Chem Soc. 2008 Jun 11;130(23):7253-5. doi: 10.1021/ja803012n. Epub 2008 May 20.
The first enantioselective total syntheses of cytotoxic macrolide amphidinolide B1 and the proposed structure for amphidinolide B2 have been accomplished. Key features of the syntheses include a diastereoselective aldol condensation, a spontaneous Wadsworth-Emmons macrocyclization and a directed epoxidation/elimination sequence.
细胞毒性大环内酯类多球壳菌素B1的首次对映选择性全合成以及多球壳菌素B2的推定结构已完成。合成的关键特征包括非对映选择性羟醛缩合、自发的沃兹沃思-埃蒙斯大环化反应以及定向环氧化/消除序列。
