• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

由伯β-烯胺基膦酸酯合成氟烷基化β-氨基膦酸酯和吡啶。

Synthesis of fluoroalkylated beta-aminophosphonates and pyridines from primary beta-enaminophosphonates.

作者信息

Palacios Francisco, Ochoa de Retana Ana M, Oyarzabal Julen, Pascual Sergio, Fernández de Trocóniz Guillermo

机构信息

Departamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco, Vitoria, Spain.

出版信息

J Org Chem. 2008 Jun 20;73(12):4568-74. doi: 10.1021/jo8005667. Epub 2008 May 20.

DOI:10.1021/jo8005667
PMID:18489181
Abstract

A simple and efficient stereoselective synthesis of fluorine containing beta-aminophosphonates by reduction of beta-enaminophosphonates is described. Reduction with sodium cyanborohydride in the presence of zinc chloride and the catalytic hydrogenation of beta-enaminophosphonates gives beta-aminophosphonates. beta-Enaminophosphonates are also used as intermediates for the regioselective synthesis of fluoroalkyl-substituted pyridines.

摘要

本文描述了一种通过β-烯胺基膦酸酯还原反应简单高效地立体选择性合成含氟β-氨基膦酸酯的方法。在氯化锌存在下用氰基硼氢化钠还原以及β-烯胺基膦酸酯的催化氢化反应均可得到β-氨基膦酸酯。β-烯胺基膦酸酯还用作区域选择性合成氟烷基取代吡啶的中间体。

相似文献

1
Synthesis of fluoroalkylated beta-aminophosphonates and pyridines from primary beta-enaminophosphonates.由伯β-烯胺基膦酸酯合成氟烷基化β-氨基膦酸酯和吡啶。
J Org Chem. 2008 Jun 20;73(12):4568-74. doi: 10.1021/jo8005667. Epub 2008 May 20.
2
Regioselective synthesis of fluoroalkylated beta-aminophosphorus derivatives and aziridines from phosphorylated oximes and nucleophilic reagents.从磷酸化肟和亲核试剂区域选择性合成氟烷基化β-氨基磷衍生物和氮丙啶。
J Org Chem. 2006 Aug 4;71(16):6141-8. doi: 10.1021/jo060865g.
3
Selective synthesis of poly-substituted fluorine-containing pyridines and dihydropyrimidines via cascade C-F bond cleavage protocol.通过级联 C-F 键断裂协议选择性合成多取代含氟吡啶和二氢嘧啶。
Org Biomol Chem. 2011 Aug 21;9(16):5682-91. doi: 10.1039/c1ob05371j. Epub 2011 Jun 29.
4
A new strategy for the synthesis of poly-substituted 3-H, 3-fluoro, or 3-trifluoromethyl pyridines via the tandem C-F bond cleavage protocol.一种通过串联 C-F 键断裂协议合成多取代 3-H、3-氟或 3-三氟甲基吡啶的新策略。
Org Lett. 2010 Oct 1;12(19):4376-9. doi: 10.1021/ol101859p.
5
Enantioselective synthesis of beta2-amino acids via Rh-catalyzed asymmetric hydrogenation with BoPhoz-type ligands: important influence of an N-H proton in the ligand on the enantioselectivity.通过铑催化、使用BoPhoz型配体的不对称氢化反应对β2-氨基酸进行对映选择性合成：配体中N-H质子对映选择性的重要影响。
J Org Chem. 2008 Mar 7;73(5):2015-7. doi: 10.1021/jo702510m. Epub 2008 Jan 30.
6
Fluorine-containing heterocycles: synthesis and some reactions of new 3-amino-2-functionalized-6-(2'-thienyl)-4-trifluoromethylthieno [2,3-b]pyridines.含氟杂环：新型3-氨基-2-官能化-6-(2'-噻吩基)-4-三氟甲基噻吩并[2,3-b]吡啶的合成及一些反应
Pharmazie. 2001 Jan;56(1):41-4.
7
[[Intramolecular alkylation of aromatic compounds. 35. Di- and tetrahydropyridinemethylindolines as potential precursors of ergolines] ].
Pharmazie. 2001 Jan;56(1):36-40.
8
The first total synthesis of alpha-D-glucopyranosyl-(1-->2)-beta-D-galactopyranosyl-O-pyridinoline, an important hallmark of human joint diseases.
Bioconjug Chem. 2005 Jul-Aug;16(4):1045-8. doi: 10.1021/bc050107h.
9
Stereoselective synthesis of quaternary center bearing azetines and their beta-amino acid derivatives.含季碳中心的氮杂环丁烷及其β-氨基酸衍生物的立体选择性合成。
J Org Chem. 2008 Feb 15;73(4):1264-9. doi: 10.1021/jo7018202. Epub 2008 Jan 11.
10
Regioselective one-step synthesis of 4-fluoroalkylated isoquinolines via carbopalladation reaction of fluorine-containing alkynes.通过含氟炔烃的碳钯化反应区域选择性一步合成4-氟烷基异喹啉。
J Org Chem. 2005 Nov 25;70(24):10172-4. doi: 10.1021/jo051700v.

引用本文的文献

1
Pyrrolidine and oxazolidine ring transformations in proline and serine derivatives of α-hydroxyphosphonates induced by deoxyfluorinating reagents.由脱氟试剂诱导的α-羟基膦酸酯脯氨酸和丝氨酸衍生物中的吡咯烷和恶唑烷环转化
RSC Adv. 2018 Jul 6;8(43):24444-24457. doi: 10.1039/c8ra05186k. eCollection 2018 Jul 2.
2
A Multicomponent Protocol for the Synthesis of Highly Functionalized γ-Lactam Derivatives and Their Applications as Antiproliferative Agents.一种用于合成高官能化γ-内酰胺衍生物的多组分方案及其作为抗增殖剂的应用。
Pharmaceuticals (Basel). 2021 Aug 9;14(8):782. doi: 10.3390/ph14080782.