Blum C, Grozdea J, Vergnes H
C R Seances Soc Biol Fil. 1976 Oct;170(3):666-71.
A TRH fixation in vitro occurs at the level of the human polynuclear neutrophil, which suggests putative membrane receptor (s) for the hypothalamic hormone. After TRH administration, enzyme modifications (myeloperoxydase, alkaline phosphatase) and metabolism changes (PAS, Sudan black) happen in vivo within the neutrophil, showing a functional activation of that blood cell. Two processes may be considered to explain those data: 1) the TRH is directly fixed, as observed in vitro; 2) a mediate hormone (TSH, T4, T3) is released capable of binding the granulocyte membrane.
促甲状腺激素释放激素（TRH）在体外可与人类多核中性粒细胞结合，这提示存在下丘脑激素的假定膜受体。给予TRH后，中性粒细胞内会在体内发生酶修饰（髓过氧化物酶、碱性磷酸酶）和代谢变化（过碘酸希夫反应、苏丹黑染色），表明该血细胞被功能性激活。可通过两个过程来解释这些数据：1）如体外观察到的那样，TRH直接结合；2）释放一种能结合粒细胞膜的介导激素（促甲状腺激素、甲状腺素、三碘甲状腺原氨酸）。
