G蛋白和钙通道的分子多样性与功能

Molecular diversity and function of G proteins and calcium channels.

作者信息

Birnbaumer L, Perez-Reyes E, Bertrand P, Gudermann T, Wei X Y, Kim H, Castellano A, Codina J

机构信息

Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030.

出版信息

Biol Reprod. 1991 Feb;44(2):207-24. doi: 10.1095/biolreprod44.2.207.

DOI:10.1095/biolreprod44.2.207

PMID:1849023

Abstract

General features of signal transduction by G proteins and structural properties of G-protein-modulated calcium channels are described. Recent results on roles of beta gamma dimers in signal transduction, on the kinetic properties of Gi alpha subunits and structural diversity of Go alpha subunits are discussed, as are the background and current state of our knowledge of the modulation of calcium channels by G proteins.

摘要

本文描述了G蛋白信号转导的一般特征以及G蛋白调节的钙通道的结构特性。讨论了βγ二聚体在信号转导中的作用、Giα亚基的动力学特性和Goα亚基的结构多样性的最新研究结果，以及我们对G蛋白调节钙通道的认识背景和现状。