左氧氟沙星和加替沙星在模拟局部眼用给药浓度时对耐氟喹诺酮和氟喹诺酮敏感的耐甲氧西林金黄色葡萄球菌菌株的抗生素后效应及杀菌活性。
Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcus aureus strains.
作者信息
Hoshi Saichi, Kikuchi Ken, Sasaki Takashi, Sotozono Chie, Kinoshita Shigeru, Hiramatsu Keiichi
机构信息
Department of Infection Control Science, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
出版信息
Antimicrob Agents Chemother. 2008 Aug;52(8):2970-3. doi: 10.1128/AAC.01466-07. Epub 2008 May 19.
Abstract
The bactericidal activities and postantibiotic effects (PAEs) of levofloxacin and gatifloxacin at concentrations corresponding to those in antibiotic eye drops against methicillin-resistant Staphylococcus aureus strains were determined. Levofloxacin and gatifloxacin at concentrations simulating those in eye drops showed lower bactericidal activities and shorter PAEs against fluoroquinolone-resistant strains than against fluoroquinolone-sensitive strains.
摘要
测定了左氧氟沙星和加替沙星在与抗生素滴眼液中浓度相当的情况下对耐甲氧西林金黄色葡萄球菌菌株的杀菌活性和抗生素后效应（PAEs）。与对氟喹诺酮敏感菌株相比，模拟滴眼液中浓度的左氧氟沙星和加替沙星对氟喹诺酮耐药菌株的杀菌活性较低，抗生素后效应较短。
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