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本文引用的文献

1
Antimicrobial resistance and ophthalmic antibiotics: 1-year results of a longitudinal controlled study of patients undergoing intravitreal injections.抗菌药物耐药性与眼科抗生素：接受玻璃体内注射患者的1年纵向对照研究结果
Arch Ophthalmol. 2011 Sep;129(9):1180-8. doi: 10.1001/archophthalmol.2011.213.
2
Clinical use of gatifloxacin ophthalmic solution for treatment of bacterial conjunctivitis.加替沙星滴眼液治疗细菌性结膜炎的临床应用
Clin Ophthalmol. 2011;5:495-502. doi: 10.2147/OPTH.S13778. Epub 2011 Apr 18.
3
In vitro time-kill experiments with besifloxacin, moxifloxacin and gatifloxacin in the absence and presence of benzalkonium chloride.在无苯扎氯铵和存在苯扎氯铵时，贝西沙星、莫西沙星和加替沙星的体外时效杀菌实验。
J Antimicrob Chemother. 2011 Apr;66(4):840-4. doi: 10.1093/jac/dkq531. Epub 2011 Jan 27.
4
Efficacy and tolerability of a combined gatifloxacin plus prednisolone formulation for topical prophylaxis after LASIK.加替沙星与泼尼松龙联合制剂用于准分子激光原位角膜磨镶术后局部预防的疗效和耐受性
Clin Ophthalmol. 2011;5:209-14. doi: 10.2147/OPTH.S17059. Epub 2011 Feb 15.
5
Microbial profile and antibiotic susceptibility of culture-positive bacterial endophthalmitis.培养阳性细菌性眼内炎的微生物谱和抗生素敏感性。
Eye (Lond). 2011 Mar;25(3):382-7; quiz 388. doi: 10.1038/eye.2010.236. Epub 2011 Feb 18.
6
Comparison of antibiotic-only and antibiotic-steroid combination treatment in corneal ulcer patients: double-blinded randomized clinical trial.抗生素单一治疗与抗生素-皮质类固醇联合治疗角膜溃疡患者的比较：双盲随机临床试验。
Can J Ophthalmol. 2011 Feb;46(1):40-5. doi: 10.3129/i10-054.
7
Sodium alginate based mucoadhesive system for gatifloxacin and its in vitro antibacterial activity.基于海藻酸钠的加替沙星粘膜粘附系统及其体外抗菌活性。
Sci Pharm. 2010 Oct-Dec;78(4):941-57. doi: 10.3797/scipharm.1004-24. Epub 2010 Sep 26.
8
Effect of fluoroquinolones on the expression of matrix metalloproteinase in debrided cornea of rats.氟喹诺酮类药物对大鼠清创角膜基质金属蛋白酶表达的影响。
Toxicol Mech Methods. 2011 Jan;21(1):6-12. doi: 10.3109/15376516.2010.529183. Epub 2010 Nov 9.
9
[Comparative research of the efficacy of the gatifloxacin and levofloxacin for bacterial conjunctivitis in human eyes].加替沙星与左氧氟沙星治疗人眼细菌性结膜炎疗效的对比研究
Zhonghua Yan Ke Za Zhi. 2010 Jun;46(6):525-31.
10
Comparison of the influence of intracameral gentamicin, gatifloxacin, and moxifloxacin on the corneal endothelium in a rabbit model.比较玻璃体内庆大霉素、加替沙星和莫西沙星对兔模型角膜内皮的影响。
Jpn J Ophthalmol. 2010 Sep;54(5):481-5. doi: 10.1007/s10384-010-0838-5. Epub 2010 Nov 5.

加替沙星眼药水治疗细菌性结膜炎：安全性、有效性及患者观点

Gatifloxacin ophthalmic solution for treatment of bacterial conjunctivitis: safety, efficacy and patient perspective.

作者信息

Schultz Clyde

机构信息

Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada. ; Biogram Inc., Ponte Vedra, FL, USA.

出版信息

Ophthalmol Eye Dis. 2012 Jul 11;4:65-70. doi: 10.4137/OED.S7383. Print 2012.

DOI:10.4137/OED.S7383
PMID:23650458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3619660/
Abstract

Gatifloxacin is a fourth generation fluroquinolone antibiotic that has been prescribed for systemic use. However, the drug which was developed by Kyorin (Japan) was linked to toxic reactions and death and was banned in the United States and Canada for use as an oral dosage form. It continues to be used as a topical application for ophthalmic conditions as the systemic toxicity seen when taking the drug orally has not been observed with ophthalmic use. The available data indicate that ocular use of gatifloxacin is safe, and effective against a broad spectrum of bacteria, including intracellular bacteria and anaerobes.

摘要

加替沙星是一种已被处方用于全身治疗的第四代氟喹诺酮类抗生素。然而，由日本杏林制药公司研发的这种药物与毒性反应及死亡有关，在美国和加拿大被禁止作为口服剂型使用。它仍被用作眼科疾病的局部用药，因为眼部使用时未观察到口服该药时出现的全身毒性。现有数据表明，眼部使用加替沙星是安全的，并且对包括细胞内细菌和厌氧菌在内的多种细菌有效。