Cao Yuchun, Zhao Jie, Lei Zhang, Shen Shiqian, Liu Cong, Li Dong, Liu Jihong, Shen Guan-Xin, Zhang Gui-Mei, Feng Zuo-Hua, Huang Bo
Department of Dermatology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
J Immunol. 2008 Jun 1;180(11):7681-6. doi: 10.4049/jimmunol.180.11.7681.
Condylomata acuminata derived from the infection of human papillomavirus is a common sexually transmitted disease. Although T cell-mediated cellular immunity is considered as the main arm against such infection, the regulation of T cell immune responses in genital condylomata is unclear to date. In this study, we analyzed FOXP3(+) regulatory T cells in genital condylomata of patients. The results show that FOXP3(+) regulatory T cells with suppressive function accumulated in large warts. Consistently, the immunosuppressive milieu in large warts was characterized by high expression of IL-10 and TGF-beta1 and low expression of IL-2 and IFN-gamma. The responsiveness of wart-infiltrating T cells both in vitro and in vivo can be increased by depleting FOXP3(+) T cells. The accumulation of FOXP3(+) regulatory T cells in large warts can be partly ascribed to the chemotaxis of CCL17 and CCL22, derived from Langerhans cells and macrophages in wart. Although such accumulation favors the local immunosuppression, it seems not to influence the systemic immunity. In conclusion, these findings demonstrate that FOXP3(+) regulatory T cells play an important role in genital condylomata, which has multiple implications in the comprehensive treatment of condylomata acuminata.
由人乳头瘤病毒感染引起的尖锐湿疣是一种常见的性传播疾病。尽管T细胞介导的细胞免疫被认为是抵抗此类感染的主要力量，但迄今为止，生殖器尖锐湿疣中T细胞免疫反应的调节尚不清楚。在本研究中，我们分析了患者生殖器尖锐湿疣中的FOXP3(+)调节性T细胞。结果显示，具有抑制功能的FOXP3(+)调节性T细胞在大的疣体中积聚。一致地，大疣体中的免疫抑制环境的特征是IL-10和TGF-β1高表达，而IL-2和IFN-γ低表达。通过耗尽FOXP3(+) T细胞，体外和体内疣体浸润T细胞的反应性均可增加。大疣体中FOXP3(+)调节性T细胞的积聚可部分归因于疣体中朗格汉斯细胞和巨噬细胞产生的CCL17和CCL22的趋化作用。尽管这种积聚有利于局部免疫抑制，但似乎并不影响全身免疫。总之，这些发现表明FOXP3(+)调节性T细胞在生殖器尖锐湿疣中起重要作用，这对尖锐湿疣的综合治疗具有多重意义。
