人参、牛黄与甘草组合对自主神经活动的影响——通过心率变异性功率谱分析及心脏去极化-复极化过程评估

Effect of the combination of ginseng, oriental bezoar and glycyrrhiza on autonomic nervous activity as evaluated by power spectral analysis of HRV and cardiac depolarization-repolarization process.

作者信息

Zheng Aisong, Moritani Toshio

机构信息

Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan.

出版信息

J Nutr Sci Vitaminol (Tokyo). 2008 Apr;54(2):148-53. doi: 10.3177/jnsv.54.148.

DOI:10.3177/jnsv.54.148

PMID:18490845

Abstract

BACKGROUND

Ginseng, oriental bezoar and glycyrrhiza are the most widespread herbs often used in Kampo. These three herbs have been used for a Kampo for a thousand years and a number of pharmacological and clinical studies have reported about their effects. However, it has not been previously described how the combination of these most commonly used herbs affects the autonomic nervous system (ANS).

OBJECTIVE

This is a randomized, double-blind, placebo-controlled experiment to examine the acute effects of Kampo on autonomic nervous activity by using power spectral analysis of heart rate variability (HRV) and cardiac depolarization-repolarization time intervals in humans.

DESIGN

Ten healthy men volunteered to participate in this study. The Kampo at a dose of two capsules contained the following ingredients: powdered ginseng 250 mg, powdered oriental bezoar 50 mg, and powdered glycyrrhiza 50 mg. The placebo capsules contained corn starch. A CM5 lead ECG was recorded before, and 30 min and 60 min after the oral administration of Kampo or a placebo on different days.

RESULTS

HF power (high frequency component in the HRV) was significantly increased and HR (heart rate) was significantly decreased after taking Kampo at 60 min (p<0.05) compared with the placebo. TP (total power) and LF power (low frequency component in the HRV) did not change significantly between the Kampo and placebo, and there were also no statistically significant differences in heart-rate-corrected ECG QT interval (QTc) or recovery time (RTc) between the Kampo and placebo. However, we observed that there was a tendency of decreased QTc interval and RTc after taking Kampo at 60 min compared with response of the placebo (p<0.1).

CONCLUSIONS

These results indicated that the Kampo mainly potentiated parasympathetic nervous activity and may be useful for cardiovascular health.

摘要

背景

人参、牛黄和甘草是汉方中最常用的草药。这三种草药用于汉方已有千年历史，并且有多项药理和临床研究报道了它们的功效。然而，此前尚未有人描述过这些最常用草药的组合对自主神经系统（ANS）有何影响。

目的

这是一项随机、双盲、安慰剂对照实验，通过对人体心率变异性（HRV）进行功率谱分析以及测量心脏去极化 - 复极化时间间隔，来研究汉方对自主神经活动的急性影响。

设计

10名健康男性自愿参与本研究。一剂两粒胶囊的汉方包含以下成分：人参粉250毫克、牛黄粉50毫克和甘草粉50毫克。安慰剂胶囊含有玉米淀粉。在不同日期口服汉方或安慰剂之前、之后30分钟和60分钟记录CM5导联心电图。

结果

与安慰剂相比，服用汉方60分钟后，高频功率（HRV中的高频成分）显著增加，心率（HR）显著降低（p<0.05）。汉方组和安慰剂组之间的总功率（TP）和低频功率（HRV中的低频成分）没有显著变化，汉方组和安慰剂组之间的心率校正心电图QT间期（QTc）或恢复时间（RTc）也没有统计学上的显著差异。然而，我们观察到与安慰剂相比，服用汉方60分钟后QTc间期和RTc有缩短趋势（p<0.1）。