Cyclic AMP level in red blood cells of Plasmodium berghei-infected Mastomys natalensis.

The present report describes the changes in cyclic AMP level which occur upon parasitization of red cells by Plasmodium berghei. Parasitized erythrocytes were separated from the non-parasitized population by percoll density-gradient centrifugation. An increase in the cyclic AMP content of both non-parasitized and parasitized erythrocytes of infected animals compared with that of uninfected animals was observed. The patterns of physiological response to isoproterenol in normal, parasitized and non-parasitized erythrocytes were identical.