[氯喹对感染伯氏疟原虫的红细胞中谷胱甘肽代谢的作用]
[Action of chloroquine on glutathione metabolism in erythrocytes parasitized by Plasmodium berghei].
作者信息
Bhatia A, Charet P
出版信息
Ann Parasitol Hum Comp. 1984;59(3):317-20.
PMID:6380377
Abstract
Chloroquine acts on erythrocytes parasitized by a P. berghei sensitive strain, inducing a dramatic decrease of the intra erythrocytic reduced glutathione. This reduction follows a decrease of the glutathione reductase activity. Contrarily when erythrocytes are parasitized by a P. berghei resistant strain neither the intra erythrocytic reduced glutathione nor the glutathione reductase activity are modified by the action of chloroquine. Glutathione metabolism could be the main target of action of chloroquine in malaria infection.
摘要
氯喹作用于被伯氏疟原虫敏感株寄生的红细胞，导致红细胞内还原型谷胱甘肽急剧减少。这种减少伴随着谷胱甘肽还原酶活性的降低。相反，当红细胞被伯氏疟原虫耐药株寄生时，氯喹的作用不会改变红细胞内还原型谷胱甘肽的含量或谷胱甘肽还原酶的活性。谷胱甘肽代谢可能是氯喹在疟疾感染中的主要作用靶点。
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