乙酰左旋肉碱和α-硫辛酸：治疗情绪障碍的潜在神经治疗药物？
Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders?
作者信息
Soczynska Joanna K, Kennedy Sidney H, Chow Cindy S M, Woldeyohannes Hanna O, Konarski Jakub Z, McIntyre Roger S
机构信息
University of Toronto, Institute of Medical Science, Toronto, ON, Canada.
出版信息
Expert Opin Investig Drugs. 2008 Jun;17(6):827-43. doi: 10.1517/13543784.17.6.827.
BACKGROUND
Mood disorders are associated with decrements in cognitive function, which are insufficiently treated with contemporary pharmacotherapies.
OBJECTIVES
To evaluate the putative neurotherapeutic effects of the mitochondrial cofactors, L-carnitine, acetyl-L-carnitine, and alpha-lipoic acid; and to provide a rationale for investigating their efficacy in the treatment of neurocognitive deficits associated with mood disorders.
METHODS
A PubMed search of English-language articles published between January 1966 and March 2007 was conducted using the search terms carnitine and lipoic acid.
RESULTS
L-carnitine and alpha-lipoic acid may offer neurotherapeutic effects (e.g., neurocognitive enhancement) via disparate mechanisms including antioxidant, anti-inflammatory, and metabolic regulation. Preliminary controlled trials in depressed geriatric populations also suggest an antidepressant effect with acetyl-L-carnitine.
CONCLUSIONS
L-carnitine and alpha-lipoic acid are pleiotropic agents capable of offering neuroprotective and possibly cognitive-enhancing effects for neuropsychiatric disorders in which cognitive deficits are an integral feature.
背景
情绪障碍与认知功能减退有关，而当代药物疗法对其治疗并不充分。
目的
评估线粒体辅助因子L-肉碱、乙酰-L-肉碱和α-硫辛酸假定的神经治疗作用；并为研究它们治疗与情绪障碍相关的神经认知缺陷的疗效提供理论依据。
方法
使用搜索词“肉碱”和“硫辛酸”对1966年1月至2007年3月发表的英文文章进行PubMed搜索。
结果
L-肉碱和α-硫辛酸可能通过不同机制发挥神经治疗作用（如神经认知增强），这些机制包括抗氧化、抗炎和代谢调节。在老年抑郁症患者中进行的初步对照试验也表明乙酰-L-肉碱具有抗抑郁作用。
结论
L-肉碱和α-硫辛酸是具有多效性的药物，能够为以认知缺陷为主要特征的神经精神疾病提供神经保护作用，并可能具有认知增强作用。
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