Maltaris Theodoros, Weigel Michael, Mueller Andreas, Schmidt Marcus, Seufert Rudolf, Fischl Franz, Koelbl Heinz, Dittrich Ralf
Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz University Hospital, Langenbeckstr, 1, 55124 Mainz, Germany.
Breast Cancer Res. 2008;10(2):206. doi: 10.1186/bcr1991. Epub 2008 Apr 29.
Aggressive chemotherapy has improved the life expectancy for reproductive-age women with breast cancer, but it often causes infertility or premature ovarian failure due to destruction of the ovarian reserve. Many questions concerning fertility preservation in breast cancer patients remain unanswered--for example, whether fertility preservation methods interfere with chemotherapy, and whether subsequent pregnancy has negative effects on the prognosis. Fertility preservation is a critical factor in decision-making for younger breast cancer patients, however, and clinicians should address this. The present article reviews the incidence of chemotherapy-induced amenorrhea, and discusses fertility-preservation options and the prognosis for patients who become pregnant after breast cancer.
积极的化疗提高了育龄期乳腺癌女性的预期寿命,但由于卵巢储备遭到破坏,化疗常常会导致不孕或卵巢早衰。许多关于乳腺癌患者生育力保存的问题仍未得到解答——例如,生育力保存方法是否会干扰化疗,以及后续妊娠是否会对预后产生负面影响。然而,生育力保存是年轻乳腺癌患者决策中的一个关键因素,临床医生应该关注这一点。本文回顾了化疗导致闭经的发生率,并讨论了生育力保存的选择以及乳腺癌患者妊娠后的预后情况。