Kao Wei-Tsung, Yen Yung-Chieh, Lung For-Wey
Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.
Lipids Health Dis. 2008 May 21;7:20. doi: 10.1186/1476-511X-7-20.
Explore the interaction between apolipoprotein E (Apo E), phospholipase A2 (PLA2) and beta2 adrenergic receptor (beta2-AR) gene polymorphisms and lipid profiles in an elderly Chinese population.
Five hundred subjects aged 65 to 74 years were randomly selected from a community in southern Taiwan to assess the relationship between Apo E, PLA2 and beta2-AR gene polymorphisms and lipid profiles. Two hundred sixty-seven participants agreed to have venous blood drawn for DNA studies.
Two statistically significant differences were noted in TC and LDL-C in the Gln27Glu of the beta2-AR gene polymorphism (P = 0.007, P = 0.022). The low-income group had a higher HDL-C level (p = 0.076). The Gln27Glu polymorphism Glu/Glu or Gln/Glu subjects had lower TC levels compared to the Gln27Glu polymorphism Gln/Gln subjects (p = 0.092). Lower TC levels (p = 0.082) and lower LDL-C levels (p = 0.045) in subjects with the Cys19Arg16Glu27 haplotype. Lower TC levels (p = 0.06) were also noted in subjects with the Cys19Gly 16Glu27 haplotype. On the other hand, higher VLDL-C levels (p = 0.185) and higher triglyceride (TG) levels (p = 0.190) were noted in subjects with the Cys19Gly 16Gln27 haplotype. The epsilon2 allele combined with low income had a positive effect on HDL-C (p = 0.0011), after adding the income factor in this study.
When the effects of Apo E and PLA2 on lipid profiles were included in this study, beta2-AR gene polymorphisms reduced significant effect on lipid profiles. Similarly, low income increased effect on HDL-C. This study appeared that the results of gene-gene and gene-environment interaction, it should be considered in further studies for lipid profiles.
探讨载脂蛋白E（Apo E）、磷脂酶A2（PLA2）和β2肾上腺素能受体（β2-AR）基因多态性与中国老年人群血脂谱之间的相互作用。
从台湾南部一个社区随机选取500名年龄在65至74岁之间的受试者，以评估Apo E、PLA2和β2-AR基因多态性与血脂谱之间的关系。267名参与者同意抽取静脉血进行DNA研究。
β2-AR基因多态性的Gln27Glu位点在总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）方面存在两个具有统计学意义的差异（P = 0.007，P = 0.022）。低收入组的高密度脂蛋白胆固醇（HDL-C）水平较高（p = 0.076）。与β2-AR基因多态性Gln/Gln受试者相比，Gln27Glu多态性的Glu/Glu或Gln/Glu受试者的TC水平较低（p = 0.092）。Cys19Arg16Glu27单倍型的受试者TC水平较低（p = 0.082），低密度脂蛋白胆固醇水平较低（p = 0.045）。Cys19Gly 16Glu27单倍型的受试者也有较低的TC水平（p = 0.06）。另一方面，Cys19Gly 16Gln27单倍型的受试者极低密度脂蛋白胆固醇水平较高（p = 0.185），甘油三酯（TG）水平较高（p = 0.190）。在本研究中加入收入因素后，ε2等位基因与低收入对HDL-C有正向影响（p = 0.0011）。
在本研究中纳入Apo E和PLA2对血脂谱的影响后，β2-AR基因多态性对血脂谱的显著影响降低。同样，低收入对HDL-C的影响增加。本研究似乎显示了基因-基因和基因-环境相互作用的结果，在进一步研究血脂谱时应予以考虑。
