Gliebus Gediminas, Lippa Carol F
Department of Neurology, Drexel University College of Medicine, New College Building, 245 North 15th Street, Philadelphia, PA 19102, USA.
Am J Alzheimers Dis Other Demen. 2007 Feb-Mar;22(1):57-61. doi: 10.1177/1533317506295889.
Adrenergic signaling is important for the retrieval of intermediate-term contextual and spatial memories. The role of norepinephrine in retrieval requires signaling through beta1-adrenergic receptors in the hippocampus. Environmental cues activate the locus ceruleus, the main adrenergic nucleus of the brain, when an environmental stimulus is memorable. This leads to norepinephrine activation in the hippocampus, which is important for retrieving memories. Although beta-blockers do not impair cognition in normal subjects, this article explores the possibility that central nervous system (CNS)-active beta-blockers could affect delayed memory in patients with cognitive impairment. The authors investigated the influence of beta-blockers on delayed memory function in cognitively impaired patients. There was a trend for worse delayed memory retrieval in patients who were on CNS-active beta-blockers. These data support the notion that common medications used in cognitively impaired elderly patients can worsen cognition and that careful selection of medications may help to maximize retrieval of newly formed memories.
肾上腺素能信号传导对于中期情境记忆和空间记忆的提取很重要。去甲肾上腺素在记忆提取中的作用需要通过海马体中的β1 - 肾上腺素能受体进行信号传导。当环境刺激令人难忘时，环境线索会激活蓝斑核，即大脑主要的肾上腺素能核团。这会导致海马体中的去甲肾上腺素激活，这对记忆提取很重要。虽然β受体阻滞剂不会损害正常受试者的认知，但本文探讨了中枢神经系统（CNS）活性β受体阻滞剂可能影响认知障碍患者延迟记忆的可能性。作者研究了β受体阻滞剂对认知障碍患者延迟记忆功能的影响。服用中枢神经系统活性β受体阻滞剂的患者存在延迟记忆提取变差的趋势。这些数据支持了这样一种观点，即认知受损老年患者常用的药物可能会使认知恶化，谨慎选择药物可能有助于最大限度地提高新形成记忆的提取。
