Parran T V, Jasinski D R
Department of Medicine, Francis Scott Key Medical Center, Baltimore, Md.
Arch Intern Med. 1991 Apr;151(4):781-3.
Data are presented from a case series of 22 patients who abused methylphenidate hydrochloride (Ritalin-SR). The abuse pattern and symptoms of toxicity were similar to that seen with cocaine hydrochloride and amphetamine sulfate addiction; yet, the morbidity and mortality seen in this case series were greater than usual for a group of patients involved in intravenous drug abuse. We describe the characteristics of the methylphenidate abuse syndrome in terms of the pharmacology of methylphenidate, the constituents of the Ritalin-SR preparation, and the disease of chemical dependence. We propose solutions to the problem of methylphenidate abuse.
本文呈现了一组22例滥用盐酸哌醋甲酯（缓释利他林）患者的病例系列数据。其滥用模式和中毒症状与盐酸可卡因和硫酸苯丙胺成瘾所见相似；然而，该病例系列中的发病率和死亡率高于一组静脉药物滥用患者的通常情况。我们从哌醋甲酯的药理学、缓释利他林制剂的成分以及化学依赖疾病方面描述了哌醋甲酯滥用综合征的特征。我们提出了应对哌醋甲酯滥用问题的解决方案。
