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Is infliximab safe to use while breastfeeding?英夫利昔单抗在哺乳期使用安全吗？
World J Gastroenterol. 2008 May 21;14(19):3085-7. doi: 10.3748/wjg.14.3085.
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Detection of infliximab in breast milk of nursing mothers with inflammatory bowel disease.检测哺乳期炎症性肠病母亲的母乳中的英夫利昔单抗。
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Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn.病例报告：母体给予的英夫利昔单抗经胎盘转移至新生儿的证据。
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The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organisation: pregnancy and pediatrics.世界胃肠病学大会与欧洲克罗恩病和结肠炎组织关于炎症性肠病生物治疗的伦敦立场声明：妊娠与儿科。
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Safety of Tumor Necrosis Factor Inhibitors during Pregnancy and Breastfeeding.肿瘤坏死因子抑制剂在妊娠和哺乳期的安全性。
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本文引用的文献

1
Safety of infliximab and other biologic agents in the inflammatory bowel diseases.英夫利昔单抗及其他生物制剂在炎症性肠病中的安全性。
Gastroenterol Clin North Am. 2006 Dec;35(4):837-55. doi: 10.1016/j.gtc.2006.09.008.
2
Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn.病例报告：母体给予的英夫利昔单抗经胎盘转移至新生儿的证据。
Clin Gastroenterol Hepatol. 2006 Oct;4(10):1255-8. doi: 10.1016/j.cgh.2006.07.018.
3
Effect of intentional infliximab use throughout pregnancy in inducing and maintaining remission in Crohn's disease.孕期全程故意使用英夫利昔单抗对诱导和维持克罗恩病缓解的影响。
Dig Liver Dis. 2006 Jun;38(6):439-40. doi: 10.1016/j.dld.2006.01.017. Epub 2006 Mar 23.
4
[Term pregnancy in a patient with Crohn's disease under treatment with adalimumab].
Gastroenterol Hepatol. 2005 Aug-Sep;28(7):435. doi: 10.1157/13077774.
5
Adalimumab use in pregnancy.妊娠期间使用阿达木单抗。
Gut. 2005 Jun;54(6):890. doi: 10.1136/gut.2005.065417.
6
Intentional infliximab use during pregnancy for induction or maintenance of remission in Crohn's disease.孕期故意使用英夫利昔单抗诱导或维持克罗恩病缓解。
Aliment Pharmacol Ther. 2005 Mar 15;21(6):733-8. doi: 10.1111/j.1365-2036.2005.02405.x.
7
Outcome of pregnancy in women receiving infliximab for the treatment of Crohn's disease and rheumatoid arthritis.接受英夫利昔单抗治疗克罗恩病和类风湿关节炎的女性的妊娠结局。
Am J Gastroenterol. 2004 Dec;99(12):2385-92. doi: 10.1111/j.1572-0241.2004.30186.x.
8
Etanercept in breast milk.
J Rheumatol. 2004 May;31(5):1017-8.
9
Placental transport of immunoglobulin G.免疫球蛋白G的胎盘转运
Vaccine. 2003 Jul 28;21(24):3365-9. doi: 10.1016/s0264-410x(03)00334-7.
10
Pregnancy and nursing in inflammatory bowel disease.炎症性肠病患者的妊娠与哺乳
Gastroenterol Clin North Am. 2002 Mar;31(1):265-73, xii. doi: 10.1016/s0889-8553(01)00015-2.

英夫利昔单抗在哺乳期使用安全吗？

Is infliximab safe to use while breastfeeding?

作者信息

Stengel Joel-Z, Arnold Hays-L

机构信息

Gastroenterology Service, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA.

出版信息

World J Gastroenterol. 2008 May 21;14(19):3085-7. doi: 10.3748/wjg.14.3085.

DOI:10.3748/wjg.14.3085
PMID:18494064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2712180/
Abstract

Inflammatory bowel disease (IBD) often affects women around the age of conception and pregnancy. Most drugs used to treat IBD are safe in pregnancy, but physicians must consider the clinical implications of certain treatment regimens in young, fertile females. We report an informative case of a pregnant patient with IBD who underwent treatment with infliximab during her pregnancy and while nursing her infant. Serum and breast milk infliximab levels were monitored throughout this time period. This case report suggests that targeted monoclonal antibodies and other biologic agents can be used with caution in pregnant and breastfeeding patients.

摘要

炎症性肠病（IBD）常常影响处于受孕年龄和孕期的女性。大多数用于治疗IBD的药物在孕期是安全的，但医生必须考虑某些治疗方案对年轻的、有生育能力的女性的临床影响。我们报告了一例IBD孕妇的病例，该患者在孕期及哺乳期接受了英夫利昔单抗治疗。在此期间全程监测了血清和母乳中的英夫利昔单抗水平。本病例报告表明，靶向单克隆抗体和其他生物制剂在孕妇和哺乳期患者中可谨慎使用。