英夫利昔单抗在哺乳期使用安全吗？
Is infliximab safe to use while breastfeeding?
作者信息
Stengel Joel-Z, Arnold Hays-L
机构信息
Gastroenterology Service, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA.
出版信息
World J Gastroenterol. 2008 May 21;14(19):3085-7. doi: 10.3748/wjg.14.3085.
Abstract
Inflammatory bowel disease (IBD) often affects women around the age of conception and pregnancy. Most drugs used to treat IBD are safe in pregnancy, but physicians must consider the clinical implications of certain treatment regimens in young, fertile females. We report an informative case of a pregnant patient with IBD who underwent treatment with infliximab during her pregnancy and while nursing her infant. Serum and breast milk infliximab levels were monitored throughout this time period. This case report suggests that targeted monoclonal antibodies and other biologic agents can be used with caution in pregnant and breastfeeding patients.
摘要
炎症性肠病（IBD）常常影响处于受孕年龄和孕期的女性。大多数用于治疗IBD的药物在孕期是安全的，但医生必须考虑某些治疗方案对年轻的、有生育能力的女性的临床影响。我们报告了一例IBD孕妇的病例，该患者在孕期及哺乳期接受了英夫利昔单抗治疗。在此期间全程监测了血清和母乳中的英夫利昔单抗水平。本病例报告表明，靶向单克隆抗体和其他生物制剂在孕妇和哺乳期患者中可谨慎使用。
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本文引用的文献
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