Gustafsson R, Fredens K, Nettelbladt O, Hällgren R
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
Arthritis Rheum. 1991 Apr;34(4):414-22. doi: 10.1002/art.1780340406.
Circulating levels of eosinophil cationic protein (ECP) were increased 4-fold in patients with systemic sclerosis (SSc) compared with those in healthy control subjects. There was no correlation between the ECP concentrations and laboratory indices of inflammatory activity or visceral involvement. Mean ECP levels were higher in patients with a history of occupational exposure to silica, even though patients who had no such history also had ECP levels higher than normal. The patients had increased bronchoalveolar levels of ECP, which correlated with impaired lung functioning. Skin infiltration with activated eosinophils and extracellular deposits of ECP were present in skin biopsy samples from the SSc patients. We conclude that eosinophil activation is part of the inflammatory process in SSc.
与健康对照受试者相比，系统性硬化症（SSc）患者循环中的嗜酸性粒细胞阳离子蛋白（ECP）水平升高了4倍。ECP浓度与炎症活动或内脏受累的实验室指标之间无相关性。有二氧化硅职业暴露史的患者平均ECP水平更高，即便没有这种暴露史的患者其ECP水平也高于正常。这些患者的支气管肺泡ECP水平升高，这与肺功能受损相关。SSc患者的皮肤活检样本中存在活化嗜酸性粒细胞的皮肤浸润和ECP的细胞外沉积。我们得出结论，嗜酸性粒细胞活化是SSc炎症过程的一部分。
