Dekmezian R, Ordóñez N G, Mackay B
University of Texas, M.D. Anderson Cancer Center, Department of Pathology, Houston 77030.
Cancer. 1991 May 1;67(9):2356-60. doi: 10.1002/1097-0142(19910501)67:9<2356::aid-cncr2820670924>3.0.co;2-t.
A unique variant of papillary lung carcinoma in a 58-year-old woman with both Clara cell and myoepithelial components is reported. The tumor was characterized by the presence of glandular spaces lined by two cell layers. The superficial (luminal) layer was made up of columnar cells with ultrastructural and immunohistochemical features of Clara cells, and occasional interspersed type 2 pneumocytes. The cells of the basal layer possessed ultrastructural and immunohistochemical features of myoepithelial cells. Myoepithelial cells have not previously been reported in a bronchioloalveolar adenocarcinoma.
报道了一名58岁女性患有的具有Clara细胞和肌上皮成分的独特乳头状肺癌变体。该肿瘤的特征是存在由两层细胞排列而成的腺腔。表层(管腔层)由具有Clara细胞超微结构和免疫组化特征的柱状细胞组成,偶尔散布有Ⅱ型肺泡上皮细胞。基底层细胞具有肌上皮细胞的超微结构和免疫组化特征。此前在细支气管肺泡腺癌中尚未报道过肌上皮细胞。