Chang K S
Cancer Res. 1976 Sep;36(9 pt.1):3294-9.
Among various strains of skin fibroblasts tested, two strains derived from xeroderma pigmentosum (XP) patients (ages 19 and 25) with neurological complications and two strains obtained from heterozygotes (ages 54 and 18) showed relatively higher susceptibility than normal age-matched controls to transformation by feline sarcoma virus (FSV). Only one strain from a normal individual also showed a high susceptibility. Generally, there was a parallelism in susceptibilities to FSV and Kirsten murine sarcoma virus (KiMsv). However, cells from normal individuals of 46 years or older exhibited high ratios of FSV:KiMSV titers which were due to their lower susceptibility to KiMSV. Cells from two XP patients (ages 25 and 22) and a heterozygote (age 18), who were in a younger age group, manifested such a differential susceptibility to FSV and KiMSV. There was a correlation between the relative sensitivity of XP cells to the cytotoxic effect of 4-nitroquinoline 1-oxide and killing effect of UV light. Pretreatment of fibroblasts from three XP patients by a subtoxic dose of 4-nitroquinoline 1-oxide 24 hr before viral infection facilitated transformation by KiMSV and FSV, whereas no such effect was observed with three normal cells strains similarly treated.
在测试的各种皮肤成纤维细胞系中，来自患有神经并发症的着色性干皮病（XP）患者（19岁和25岁）的两个细胞系以及来自杂合子（54岁和18岁）的两个细胞系，相较于年龄匹配的正常对照，对猫肉瘤病毒（FSV）转化表现出相对较高的敏感性。仅来自一名正常个体的一个细胞系也显示出高敏感性。一般来说，对FSV和 Kirsten 小鼠肉瘤病毒（KiMsv）的敏感性存在平行关系。然而，46岁及以上正常个体的细胞表现出较高的FSV:KiMSV滴度比，这是由于它们对KiMsv的敏感性较低。来自两名年龄较小的XP患者（25岁和22岁）以及一名杂合子（18岁）的细胞表现出对FSV和KiMsv的这种差异敏感性。XP细胞对4-硝基喹啉1-氧化物的细胞毒性作用和紫外线杀伤作用的相对敏感性之间存在相关性。在病毒感染前24小时，用亚毒性剂量的4-硝基喹啉1-氧化物预处理三名XP患者的成纤维细胞，可促进KiMsv和FSV的转化，而对同样处理的三个正常细胞系未观察到这种效果。
