Drenckhahn D, Lüllmann-Rauch R
Cell Tissue Res. 1976 Aug 20;171(2):273-6. doi: 10.1007/BF00219411.
This study deals with the effects of two amphiphilic lipidosis-inducing drugs (chlorphentermine, iprindole) upon the ultrastructure of peripheral nerves of rats. After prolonged drug treatment the preterminal and terminal axoplasm of motor and sensory nerves within skeletal muscles contain numerous abnormal inclusions (osmiophilic conglomerates, autophagic vacuoles, lamellated bodies). By contrast, the axons within large peripheral nerves are little effected. The present observations are tentatively interpreted as resulting from interference with catabolic processes involved in the normal turnover of axoplasmic constituents at the nerve terminal. The exact pathogenesis and the functional significance of these alterations remain to be elucidated.
本研究探讨了两种诱导两亲性脂质沉积的药物（氯苯丁胺、茚满二酮）对大鼠外周神经超微结构的影响。经过长时间药物治疗后，骨骼肌内运动神经和感觉神经的终末前和终末轴浆含有大量异常包涵体（嗜锇聚集体、自噬空泡、层状体）。相比之下，大型外周神经内的轴突受影响较小。目前的观察结果初步解释为是由于干扰了神经末梢轴浆成分正常周转所涉及的分解代谢过程。这些改变的确切发病机制和功能意义仍有待阐明。
