Lüllmann-Rauch B
Virchows Arch B Cell Pathol. 1975;18(1):51-60. doi: 10.1007/BF02889233.
Histological, histochemical and ultrastructural examinations were performed on renal tissues of rats after prolonged oral administration of the anorectic drug chlorphentermine or of the tricyclic antidepressants iprindole, imipramine and clomipramine. All drugs caused the formation of multilamellated cytoplasmic inclusions throughout the nephron and the collecting duct system, and in interstitial cells. The cytological alterations were most prominent in the glomerular podocytes, in the proximal convoluted tubules, and in the collecting duct system. In view of the histochemical properties (staining with Baker's acid hematein) and the ultrastructural appearance of the cytoplasmic inclusions the cellular alterations are interpreted as a renal manifestation of a generalized lipidosis induced by drugs of amphiphilic character.
对大鼠长期口服食欲抑制药氯苯丁胺或三环类抗抑郁药茚满二氮卓、丙咪嗪和氯米帕明后的肾组织进行了组织学、组织化学和超微结构检查。所有药物均导致整个肾单位、集合管系统以及间质细胞中形成多层细胞质包涵体。细胞学改变在肾小球足细胞、近端曲管和集合管系统中最为显著。鉴于细胞质包涵体的组织化学特性（用贝克酸性苏木精染色）和超微结构外观，细胞改变被解释为由两亲性药物诱导的全身性脂肪变性的肾脏表现。
