Li Zheng-xiao, Ji Fan-pu, Peng Zhen-hui, Wang Ke
Department of Dermatology, Xi'an Jiaotong University, Xi'an 710004, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2008 Apr;28(4):545-7.
To examine the expressions of E-cadherin, beta-catenin and cyclin D1 in the skin lesions of patients with psoriasis vulgaris, and understand their possible roles in keratinocyte hyperproliferation in these patients.
Immunohistochemistry was performed to detect the expressions of E-cadherin, beta-catenin and cyclin D1 in the normal skin tissues and psoriatic lesions.
In normal skin tissues, positive staining for E-cadherin and beta-catenin was detected in all layers of the normal epidermis at the sites of cell-cell junctions, and downregulation of E-cadherin and beta-catenin expression was found in the granular layer and basal layer of the psoriatic lesions. Cyclin D1 overexpression was observed mainly in the basal layer of the lesions, which was correlated to abnormal expression of beta-catenin.
Downregulation of E-cadherin and beta-catenin expression and cyclin D1 overexpression in psoriatic skin are probably involved in keratinocyte hyperproliferation in psoriasis vulgaris.
检测寻常型银屑病患者皮损中E-钙黏蛋白、β-连环蛋白和细胞周期蛋白D1的表达情况，了解它们在这些患者角质形成细胞过度增殖中可能发挥的作用。
采用免疫组织化学法检测正常皮肤组织和银屑病皮损中E-钙黏蛋白、β-连环蛋白和细胞周期蛋白D1的表达。
在正常皮肤组织中，E-钙黏蛋白和β-连环蛋白在表皮各层细胞间连接处呈阳性染色，而在银屑病皮损的颗粒层和基底层发现E-钙黏蛋白和β-连环蛋白表达下调。细胞周期蛋白D1过表达主要见于皮损的基底层，且与β-连环蛋白的异常表达相关。
银屑病皮肤中E-钙黏蛋白和β-连环蛋白表达下调以及细胞周期蛋白D1过表达可能参与了寻常型银屑病角质形成细胞的过度增殖。
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