[E-钙黏蛋白和β-连环蛋白在鲍恩病和鳞状细胞癌中的表达]
[Expression of E-cadherin and beta-catenin in Bowen's disease and squamous cell carcinoma].
作者信息
Li Zheng-xiao, Peng Zhen-hui, Ji Fan-pu, Yuan Jing-yi, Pan Min, Liu Yan, Wang Qiong
机构信息
Department of Dermatology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2006 Aug;26(8):1245-7.
OBJECTIVE
To investigate the involvement of E-cadherin-catenin adhesion system in Bowen's disease (BD) and cutaneous squamous cell carcinoma (SCC).
METHODS
Fifteen normal skin, 28 BD and 18 SCC specimens were stained with monoclonal antibodies against E-cadherin and beta-catenin. Evaluation of the staining results was performed with semi-quantification of the pattern and intensity of staining, percentage of positive cells, and cytoplasmic staining.
RESULT
Normal skins strongly expressed membranous E-cadherin and beta-catenin, but their expression was remarkably reduced in BD and SCC. Abnormal staining of beta-catenin was observed in the cytoplasm or cell nuclei of BD and SCC.
CONCLUSION
Abnormal expression of the E-cadherin/catenin complex is common in SCC and BD.
目的
探讨E-钙黏蛋白-连环蛋白黏附系统在鲍恩病（BD）和皮肤鳞状细胞癌（SCC）中的作用。
方法
采用抗E-钙黏蛋白和β-连环蛋白的单克隆抗体对15例正常皮肤、28例BD和18例SCC标本进行染色。通过对染色模式和强度、阳性细胞百分比及细胞质染色进行半定量来评估染色结果。
结果
正常皮肤强烈表达膜性E-钙黏蛋白和β-连环蛋白，但在BD和SCC中其表达显著降低。在BD和SCC的细胞质或细胞核中观察到β-连环蛋白的异常染色。
结论
E-钙黏蛋白/连环蛋白复合物的异常表达在SCC和BD中很常见。
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