De Simone R, Ramacci M T, Aloe L
Institute of Neurobiology, C.N.R., Rome, Italy.
Int J Dev Neurosci. 1991;9(1):39-46. doi: 10.1016/0736-5748(91)90071-s.
It has been shown that the endogenous compound, acetyl-L-carnitine (ALCAR), acts in the brain as a metabolic cofactor in the synthesis of acetylcholine. In these studies, ALCAR was injected into the brain of developing rats every other day for the first three weeks after birth in order to assess its effect on forebrain cholinergic neurons. The results showed that intracerebroventricular (icv) administration of ALCAR causes an increase of choline acetyltransferase (ChAT) activity and of nerve growth factor receptor expression in the striatum. Biological assays of brain tissues revealed that the level of nerve growth factor (NGF) in the hippocampus also increases. The ability of brain cholinergic tissues to respond to exogenous administration of ALCAR is discussed.
研究表明，内源性化合物乙酰 - L - 肉碱（ALCAR）在大脑中作为合成乙酰胆碱的代谢辅助因子发挥作用。在这些研究中，为了评估其对前脑胆碱能神经元的影响，在出生后的前三周每隔一天将ALCAR注射到发育中的大鼠脑中。结果表明，脑室内（icv）给予ALCAR会导致纹状体中胆碱乙酰转移酶（ChAT）活性和神经生长因子受体表达增加。脑组织的生物学分析显示海马体中神经生长因子（NGF）水平也会升高。文中还讨论了脑胆碱能组织对外源性给予ALCAR的反应能力。
