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渥太华小组关于纤维肌痛管理中强化锻炼的循证临床实践指南:第2部分。

Ottawa Panel evidence-based clinical practice guidelines for strengthening exercises in the management of fibromyalgia: part 2.

作者信息

Brosseau Lucie, Wells George A, Tugwell Peter, Egan Mary, Wilson Keith G, Dubouloz Claire-Jehanne, Casimiro Lynn, Robinson Vivian A, McGowan Jessie, Busch Angela, Poitras Stéphane, Moldofsky Harvey, Harth Manfred, Finestone Hillel M, Nielson Warren, Haines-Wangda Angela, Russell-Doreleyers Marion, Lambert Kim, Marshall Alison D, Veilleux Line

机构信息

Clinical Epidemiology Unit, Ottawa Hospital Research Institute, Ottawa Hospital, Civic Campus, Ottawa, Ontario, Canada.

出版信息

Phys Ther. 2008 Jul;88(7):873-86. doi: 10.2522/ptj.20070115. Epub 2008 May 22.

Abstract

BACKGROUND AND PURPOSE

The objective of this study was to create guidelines for the use of strengthening exercises in the management of adult patients (>18 years of age) with fibromyalgia (FM), as defined by the 1990 American College of Rheumatology criteria.

METHODS

Following Cochrane Collaboration methods, the Ottawa Methods Group found and synthesized evidence from comparative controlled trials and formed the Ottawa Panel, with nominated experts from key stakeholder organizations. The Ottawa Panel then developed criteria for grading the recommendations based on experimental design (I for randomized controlled trials, II for nonrandomized studies) and strength of evidence (A, B, C+, C, D+, D, or D-). From the rigorous literature search, 5 randomized controlled trials were selected. Statistical analysis was based on Cochrane Collaboration methods. Continuous data were calculated with weighted mean differences between the intervention and control groups, and dichotomous data were analyzed with relative risks. Clinical improvement was calculated using absolute benefit and relative difference in change from baseline. Clinical significance was attained when an improvement of 15% relative to a control was found.

RESULTS

There were 5 positive recommendations: 2 grade A and 3 grade C+. All 5 were of clinical benefit.

DISCUSSION AND CONCLUSION

The Ottawa Panel recommends strengthening exercises for the management of fibromyalgia as a result of the emerging evidence (grades A, B, and C+, although most trials were rated low quality) shown in the literature.

摘要

背景与目的

本研究的目的是制定针对1990年美国风湿病学会标准所定义的成年纤维肌痛(FM)患者(年龄>18岁)进行强化锻炼管理的指南。

方法

按照Cochrane协作网方法,渥太华方法小组查找并综合了来自对照试验的证据,并组建了渥太华小组,成员包括来自关键利益相关组织的指定专家。渥太华小组随后根据实验设计(随机对照试验为I级,非随机研究为II级)和证据强度(A、B、C+、C、D+、D或D-)制定了推荐分级标准。通过严格的文献检索,选取了5项随机对照试验。统计分析基于Cochrane协作网方法。连续数据采用干预组与对照组之间的加权平均差进行计算,二分数据采用相对风险进行分析。临床改善情况通过绝对获益和相对于基线变化的相对差异来计算。当发现相对于对照组有15%的改善时,即达到临床意义。

结果

有5项阳性推荐:2项为A级,3项为C+级。所有5项均具有临床益处。

讨论与结论

鉴于文献中显示的新证据(A级、B级和C+级,尽管大多数试验质量评级较低),渥太华小组推荐采用强化锻炼来管理纤维肌痛。

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