Surgucheva Irina, Surguchov Andrei
Retinal Biology Research Laboratory, Veterans Administration Medical Center, 4801 East Linwood Boulevard, Kansas City, MO 64128, USA.
J Mol Neurosci. 2008 Jul;35(3):267-71. doi: 10.1007/s12031-008-9074-6. Epub 2008 May 23.
Gamma-synuclein, also referred to as breast-cancer-specific gene 1, is the third member of the neuronal protein family synuclein. Synucleins attracted the attention of many investigators because of their role in human diseases. Gamma-synuclein participates in the pathogenesis of several types of cancer and some neurodegenerative diseases. Its role in tumorigenesis is due to the upregulation of transcription and the effect on downstream targets, including signaling pathways and transcription factors. Gamma-synuclein is also expressed in neurons and glial cells, but the regulation of its expression, as well as the mechanism of transition from normal functions to pathology in these cell types, is not studied. Here, we examined how gamma-synuclein promoter is regulated in neuronal and glial cells. We also show that gamma-synuclein is able to bind directly to several transcription factors. These results are discussed in connection with the implication of gamma-synuclein in diseases.
γ-突触核蛋白，也被称为乳腺癌特异性基因1，是神经元蛋白家族突触核蛋白的第三个成员。由于其在人类疾病中的作用，突触核蛋白吸引了众多研究者的关注。γ-突触核蛋白参与了多种癌症和一些神经退行性疾病的发病机制。它在肿瘤发生中的作用归因于转录上调以及对下游靶点的影响，包括信号通路和转录因子。γ-突触核蛋白也在神经元和神经胶质细胞中表达，但其表达的调控以及在这些细胞类型中从正常功能转变为病理状态的机制尚未得到研究。在这里，我们研究了γ-突触核蛋白启动子在神经元和神经胶质细胞中是如何被调控的。我们还表明，γ-突触核蛋白能够直接与多种转录因子结合。结合γ-突触核蛋白在疾病中的意义对这些结果进行了讨论。
