Ma Brigette B Y, Hui Edwin P, Chan Anthony T C
Department of Clinical Oncology at the Sir Y. K. Pao Center for Cancer, Prince of Wales Hospital, Ngan Shing Street, Shatin, New Territories, Hong Kong SAR, China.
Cancer Sci. 2008 Jul;99(7):1311-8. doi: 10.1111/j.1349-7006.2008.00836.x. Epub 2008 May 21.
Systemic therapy is an integral part of the management of non-keratinizing nasopharyngeal carcinoma (NPC). The purposes of this review are to provide the latest results and future directions of clinical and translational research for this disease, and to illustrate how some of these new therapies have improved the treatment outcome for patients with NPC. Particular attention will be paid to the clinical application of chemotherapy in the adjunctive treatment of locoregionally advanced NPC, novel targeted drugs, Epstein-Barr virus-targeted vaccine therapies, and the use of plasma Epstein-Barr virus DNA as a biomarker for selecting patients for adjunctive therapies.
全身治疗是未角化鼻咽癌(NPC)管理的一个组成部分。本综述的目的是提供该疾病临床和转化研究的最新结果及未来方向,并阐述其中一些新疗法如何改善了NPC患者的治疗结果。将特别关注化疗在局部区域晚期NPC辅助治疗中的临床应用、新型靶向药物、爱泼斯坦-巴尔病毒靶向疫苗疗法,以及使用血浆爱泼斯坦-巴尔病毒DNA作为选择辅助治疗患者的生物标志物。