Bechara Falk Georges, Sand M, Potthoff A, Altmeyer P, Brockmeyer N H
Department of Dermatology and Allergology, Ruhr-University Bochum, St. Josef Hospital, Gudrunstr. 56, 44791 Bochum, Germany.
Eur J Med Res. 2008 Mar 31;13(3):93-9.
Highly active antiretroviral therapy (HAART) has dramatically improved the life expectancy for HIV-infected patients. Long-term complications of both HIV-infection and antiretroviral agents are therefore of increasing concern. Facial lipoatrophy (FLA) is a stigmatizing complication associated with sever social impact and a reduced quality of life for the patient. - We aimed to review the treatment options of HIV-associated FLA. The current treatments available for treating FLA are limited and can be classified in three main categories: I. Medial therapy, II. Injectables with different duration of effect, and III. Surgical treatment options. Medical therapy can provide a small benefit but improvement is, at best, slow and partial. Injectables can yield marked results but are costly, time consuming and may be associated with complications such as granuloma formation. Surgical options such as augmentation with specially designed silicone implants may be of benefit for severe cases of FLA, however, they are associated with higher surgical complications and do not account for the dynamic process of FLA. - To summarize, until today no ideal strategies for treatment of HIV-associated FLA are available, and new therapies are strongly required. heart disease.
高效抗逆转录病毒疗法（HAART）显著提高了HIV感染患者的预期寿命。因此，HIV感染和抗逆转录病毒药物的长期并发症日益受到关注。面部脂肪萎缩（FLA）是一种具有污名化的并发症，会对患者造成严重的社会影响并降低其生活质量。——我们旨在综述HIV相关FLA的治疗选择。目前可用于治疗FLA的方法有限，主要可分为三大类：一、药物治疗；二、效果持续时间不同的注射剂；三、手术治疗选择。药物治疗能带来些许益处，但改善程度充其量缓慢且有限。注射剂可产生显著效果，但成本高昂、耗时，且可能伴有诸如肉芽肿形成等并发症。诸如使用特制硅胶植入物进行填充等手术选择，对于严重的FLA病例可能有益，然而，它们会带来更高的手术并发症风险，且无法应对FLA的动态变化过程。——总之，直至今日，尚无理想的治疗HIV相关FLA的策略，强烈需要新的治疗方法。心脏病。
