van Buul J D, Hordijk P L
Sanquin Research and Landsteiner Laboratory, Department Molecular Cell Biology, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.
Transfus Clin Biol. 2008 Feb-Mar;15(1-2):3-6. doi: 10.1016/j.tracli.2008.04.002. Epub 2008 May 23.
Leukocyte transendothelial migration is controlled by chemokine-induced signalling in leukocytes and integrin-ligand-induced bidirectional signalling in both leukocytes and endothelial cells. It is now generally accepted that endothelial signalling following leukocyte adhesion, serves to facilitate the crossing of the endothelium, be it via the paracellular or transcellular route. This brief overview discusses the main findings within this area and highlights some recent findings that shed new light on adhesion-induced signalling in the context of leukocyte transendothelial migration.
白细胞跨内皮迁移受趋化因子诱导的白细胞信号传导以及白细胞和内皮细胞中整合素-配体诱导的双向信号传导控制。现在普遍认为，白细胞黏附后的内皮信号传导有助于促进白细胞穿过内皮，无论是通过细胞旁途径还是跨细胞途径。本简要概述讨论了该领域的主要发现，并强调了一些最近的发现，这些发现为白细胞跨内皮迁移背景下的黏附诱导信号传导提供了新的线索。
