Hordijk Peter L
Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, the Netherlands.
FEBS J. 2006 Oct;273(19):4408-15. doi: 10.1111/j.1742-4658.2006.05440.x. Epub 2006 Sep 5.
The notion that it takes two to tango is certainly true for leukocyte transendothelial migration. A growing pallet of leukocyte adhesion-induced signaling events in endothelial cells have been identified, mediating both short-term (i.e. permeability) as well as long-term (i.e. regulation of transcription) effects. Efficient paracellular migration (i.e. through endothelial cell-cell junctions) requires both intracellular calcium and the actin cytoskeleton, but also involves small GTPases, reactive oxygen species and protein kinases. The alternative route of transcellular migration appears to depend on components such as caveolae and intermediate filaments. This minireview discusses our current knowledge on the regulation of leukocyte transmigration through endothelial signalling.
“一个巴掌拍不响”这一观点对于白细胞跨内皮迁移而言确实如此。在内皮细胞中，越来越多由白细胞黏附引发的信号转导事件已被识别出来，它们介导短期效应（如通透性）以及长期效应（如转录调控）。高效的旁细胞迁移（即通过内皮细胞间连接）既需要细胞内钙和肌动蛋白细胞骨架，也涉及小GTP酶、活性氧和蛋白激酶。跨细胞迁移的另一条途径似乎取决于诸如小窝和中间丝等成分。这篇迷你综述讨论了我们目前关于通过内皮信号调控白细胞迁移的知识。
