Herrera-Guzmán Ixchel, Gudayol-Ferré Esteve, Lira-Mandujano Jennifer, Herrera-Abarca Jorge, Herrera-Guzmán Daniel, Montoya-Pérez Karina, Guardia-Olmos Joan
Clínica de Enfermedades Crónicas y de Procedimientos Especiales, Morelia, Michoacán, Mexico.
Psychiatry Res. 2008 Jul 15;160(1):72-82. doi: 10.1016/j.psychres.2007.04.012. Epub 2008 May 23.
Cognitive effects of antidepressants and cognitive predictors of antidepressant treatment response are recent focuses of interest in the neuropsychology of depression. We studied the cognitive predictors of treatment response to bupropion and its neuropsychological effects in patients with major depressive disorder. Twenty subjects meeting the DSM-IV criteria for major depressive disorder were assessed with the Hamilton Depression Rating Scale and a neuropsychological battery. Subjects were medicated with 150 mg/day of bupropion sustained release for 8 weeks. At the end of the trial, 12 subjects were classified as responders to treatment and 8 were non-responders. Our findings suggest that low pretreatment measures of visual memory and low levels of mental processing speed are predictive of good response to bupropion. The cognitive effects of bupropion after the treatment showed that patients improved in visual memory measures and in mental processing speed. Our results suggest that cognitive predictors of treatment response to bupropion and cognitive effects of bupropion in patients with major depressive disorder could be closely related. These findings need to be replicated due to the exploratory nature of the present work.
抗抑郁药的认知效应以及抗抑郁治疗反应的认知预测因素是近期抑郁症神经心理学领域的研究热点。我们研究了安非他酮治疗反应的认知预测因素及其对重度抑郁症患者的神经心理学影响。对20名符合DSM-IV重度抑郁症标准的受试者进行了汉密尔顿抑郁量表和一套神经心理学测试。受试者服用150毫克/天的缓释安非他酮，持续8周。试验结束时，12名受试者被归类为治疗反应者，8名受试者为无反应者。我们的研究结果表明，治疗前视觉记忆测量值较低以及心理加工速度较低预示着对安非他酮治疗反应良好。治疗后安非他酮的认知效应表明，患者在视觉记忆测量和心理加工速度方面有所改善。我们的结果表明，重度抑郁症患者对安非他酮治疗反应的认知预测因素与安非他酮的认知效应可能密切相关。由于本研究具有探索性，这些发现需要重复验证。
