Borrello Maria Grazia, Degl'Innocenti Debora, Pierotti Marco A
Department of Experimental Oncology, Operative Unit Molecular Mechanisms of Cancer Growth and Progression, IRCCS Istituto Nazionale dei Tumori Foundation, Via G. Venezian, 1 20133 Milan, Italy.
Cancer Lett. 2008 Aug 28;267(2):262-70. doi: 10.1016/j.canlet.2008.03.060. Epub 2008 May 23.
Inflammation has long been suspected to contribute to tumor growth. However, the concept that oncogenes, known for decades as responsible for cell neoplastic transformation, build up an inflammatory pro-tumorigenic microenvironment is emerging only in the last few years. The well known oncogenes RAS and MYC have been causally linked to tumor angiogenesis through different ways. Moreover, in thyroid tumors, where many of the genetic tumor-initiating events have been identified, the oncogenes driving tumorigenesis were proved able to induce an inflammatory program. This minireview will focus on growing evidence implicating the role of intrinsic, oncogene-driven pathways leading to pro-tumoral inflammation.
长期以来，人们一直怀疑炎症会促进肿瘤生长。然而，致癌基因（数十年来一直被认为是导致细胞发生肿瘤性转化的原因）构建促肿瘤发生的炎症微环境这一概念，直到最近几年才出现。著名的致癌基因RAS和MYC已通过不同方式与肿瘤血管生成存在因果联系。此外，在甲状腺肿瘤中，许多引发肿瘤的遗传事件已被确定，驱动肿瘤发生的致癌基因被证明能够诱导炎症程序。本综述将聚焦于越来越多的证据，这些证据表明内在的、致癌基因驱动的途径在导致促肿瘤炎症方面所起的作用。
