Kakumoto Akinari, Jamiyan Tsengelmaa, Kuroda Hajime, Harada Oi, Yamaguchi-Isochi Tomomi, Baba Shogo, Kato Yasutaka, Nishihara Hiroshi, Kawami Hiroyuki
Department of Diagnostic Pathology, Tokyo Women's Medical University Adachi Medical Center 4-33-1 Kohoku Adachi-Ku, Tokyo 123-0872, Japan.
Department of Pathology and Forensic Medicine, Mongolian National University of Medical Sciences Ulan Bator 14210, Mongolia.
Int J Clin Exp Pathol. 2024 Mar 15;17(3):51-62. doi: 10.62347/JQDQ1527. eCollection 2024.
Neutrophils are the most common type of leukocyte in mammals and play an essential role in the innate immune system and anti-cancer responses. However, recent studies identified the presence of tumor-associated neutrophils (TANs) as a poor prognostic factor. The present study investigated whether relationships exist between TANs and the clinicopathological factors and genetic status of breast cancer.
A total of 196 breast cancer patients with sufficient biopsy, breast-conserving surgery, or mastectomy specimens between 2014 and 2021 in Hokuto Hospital were included.
TANs were individually counted in the tumor stroma (TS) and tumor nest (TN). A higher density of TANs in both TS and TN correlated with tumor size (TS = 0.010; TN = 0.001), a high histological grade (TS < 0.001; TN < 0.001), the histological type (TS = 0.009; TN = 0.034), a high ratio of lymph node metastasis (TS < 0.001; TN < 0.001), an advanced stage of cancer (TS < 0.001; TN = 0.002), intrinsic subtypes (TS < 0.001; TN < 0.001), (TS < 0.001; TN < 0.001), (TS = 0.002; TN = 0.023), and (TS < 0.001; TN < 0.001). A higher density of TANs in TS and TN also correlated with shorter disease-free survival and overall survival ( < 0.001).
The present results suggest that a higher density of TANs correlates with unfavorable prognostic factors in breast cancer. Further research on clinicopathological and genetic factors associated with TANs in breast cancer is needed.
中性粒细胞是哺乳动物中最常见的白细胞类型，在先天免疫系统和抗癌反应中发挥着重要作用。然而，最近的研究发现肿瘤相关中性粒细胞（TANs）的存在是一个不良预后因素。本研究调查了TANs与乳腺癌的临床病理因素和基因状态之间是否存在关联。
纳入了2014年至2021年期间在北斗医院接受充分活检、保乳手术或乳房切除术的196例乳腺癌患者。
在肿瘤基质（TS）和肿瘤巢（TN）中分别对TANs进行计数。TS和TN中TANs的较高密度与肿瘤大小相关（TS = 0.010；TN = 0.001）、高组织学分级（TS < 0.001；TN < 0.001）、组织学类型（TS = 0.009；TN = 0.034）、高淋巴结转移率（TS < 0.001；TN < 0.001）、癌症晚期（TS < 0.001；TN = 0.002）、内在亚型（TS < 0.001；TN < 0.001）、（TS < 0.001；TN < 0.001）、（TS = 0.002；TN = 0.023）以及（TS < 0.001；TN < 0.001）相关。TS和TN中TANs的较高密度也与无病生存期和总生存期较短相关（< 0.001）。
目前的结果表明，TANs的较高密度与乳腺癌的不良预后因素相关。需要对乳腺癌中与TANs相关的临床病理和基因因素进行进一步研究。
