Frazer Ian H
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Queensland 4102, Australia.
J Autoimmun. 2008 Nov;31(3):216-8. doi: 10.1016/j.jaut.2008.04.014. Epub 2008 May 27.
Organ specific autoimmunity follows induction and perpetuation of cell mediated immune effector responses to antigens expressed by somatic cells of the target organ, and clearance of persistent viral infection requires a similar immune response. Research on regulators of innate and adaptive immunity that hinder clearance of viral infection may therefore shed light on genetic factors predisposing to organ specific autoimmunity. This article discusses Ian Mackay's interests in autoimmunity when I was his assistant physician, and their influence on my group's subsequent research on persistent viral infection.
器官特异性自身免疫是在针对靶器官体细胞所表达抗原的细胞介导免疫效应反应被诱导并持续存在之后出现的，而清除持续性病毒感染也需要类似的免疫反应。因此，对阻碍病毒感染清除的先天性和适应性免疫调节因子的研究可能会揭示易患器官特异性自身免疫的遗传因素。本文讨论了我在担任伊恩·麦凯的助理医师期间，他对自身免疫的兴趣，以及这些兴趣对我们团队随后关于持续性病毒感染研究的影响。
